Clinico-pathological significance of RCAS1 expression in gliomas: A potential mechanism of tumor immune escape
| Autor: | Shoko M. Yamada, Keiji Shimizu, Shinichi Toyonaga, Hiromichi Nakabayashi, Mitsuhiro Hara, Manabu Nakashima, Kae Chang Park |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent T-Lymphocytes Apoptosis chemical and pharmacologic phenomena Kaplan-Meier Estimate Biology Lymphocytes Tumor-Infiltrating Antigen Antigens Neoplasm Glioma medicine Humans Child Aged Proportional Hazards Models Aged 80 and over Analysis of Variance Tumor-infiltrating lymphocytes Tumor Immune Escape Middle Aged Prognosis medicine.disease Immunohistochemistry Ki-67 Antigen Oncology Tumor progression Leukocyte Common Antigens Female Infiltration (medical) |
| Zdroj: | Cancer Letters. 246:182-189 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2006.02.021 |
| Popis: | RCAS1, one of the tumor cell surface antigens, is strongly expressed in aggressive tumors. RCAS1 suppresses the in vitro growth of immune effector cells. We investigated the expression of RCAS1 in 57 gliomas using immunohistochemistry. Furthermore, we examined the association of the RCAS1 expression with the infiltration of tumor infiltrating lymphocyte (TIL). RCAS1 overexpression was significantly correlated with high histological grade and poor prognosis. Reduced infiltration and increased apoptosis of TILs was observed in RCAS1-positive regions. Apoptotsis of TILs appeared to be induced by RCAS1. RCAS1 expression in gliomas may play roles in tumor progression and tumor immune escape. |
| Databáze: | OpenAIRE |
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