Placental CpG Methylation of Inflammation, Angiogenic, and Neurotrophic Genes and Retinopathy of Prematurity
| Autor: | Olaf Dammann, Raina N. Fichorova, Rebecca C. Fry, Deborah K. VanderVeen, Catherine M. Bulka, Lisa Smeester, Hudson P. Santos, T. Michael O'Shea |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine retinopathy of prematury Placenta Gestational Age Inflammation angiogenesis 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Neurotrophic factors Odds Ratio medicine Humans Retinopathy of Prematurity Nerve Growth Factors Serum amyloid A Angiogenic Proteins business.industry Clinical and Epidemiologic Research Infant Newborn Retinopathy of prematurity General Medicine Methylation neurotrophic DNA Methylation medicine.disease 3. Good health 030104 developmental biology medicine.anatomical_structure CpG site Infant Extremely Low Birth Weight Infant Extremely Premature DNA methylation 030221 ophthalmology & optometry Cancer research Intercellular Signaling Peptides and Proteins CpG Islands Female methylation medicine.symptom business |
| Zdroj: | Investigative Ophthalmology & Visual Science |
| ISSN: | 1552-5783 |
| DOI: | 10.1167/iovs.18-26466 |
| Popis: | Purpose Extremely preterm infants are at increased risk for retinopathy of prematurity (ROP). We previously identified several inflammatory proteins that were expressed early in life and are associated with an increased risk of ROP and several angiogenic and neurotrophic growth factors in the neonatal systemic circulation that are associated with a lower risk of ROP. In this paper, we report the results of a set of analyses designed to test the hypothesis that placental CpG methylation levels of 12 inflammation-, angiogenic-, and neurotrophic-associated genes predict the occurrence of prethreshold ROP in extremely preterm newborns. Methods We used placental CpG methylation data from 395 newborns from the Extremely Low Gestational Age Newborns study. Results Multivariable regression models revealed that placental DNA methylation of 16 CpG sites representing 8 genes were associated with prethreshold ROP. Specifically, CpG methylation in the serum amyloid A SAA1 and SAA2, brain-derived neurotrophic factor (BDNF), myeloperoxidase (MPO), C-reactive protein (CRP), angiopoietin 1 (ANGPT1), and tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) genes was associated with a lower risk of prethreshold ROP. Conversely, CpG methylation at three probes within tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and in two alternative probes within the BDNF and ANGPT1 genes was associated with an increased risk of ROP. Conclusions CpG methylation may be a useful marker for improving ROP prediction, opening the opportunity for early intervention to lessen disease severity. |
| Databáze: | OpenAIRE |
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