Key role of the sympathetic microenvironment for the interplay of tumour necrosis factor and interleukin 6 in normal but not in inflamed mouse colon mucosa
| Autor: | Frieder Kees, Rainer H. Straub, J. Schölmerich, K Stebner, Werner Falk, Peter Härle |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system Sympathetic Nervous System Adrenergic receptor Epithelial Cell Biology Colon Biology Proinflammatory cytokine Mice Norepinephrine Intestinal mucosa Internal medicine Receptors Adrenergic beta medicine Animals Secretion Intestinal Mucosa Receptor Interleukin 6 Mice Inbred BALB C Interleukin-6 Tumor Necrosis Factor-alpha Macrophages Gastroenterology Isoproterenol Antibodies Monoclonal Adrenergic beta-Agonists Colitis Immunohistochemistry Electric Stimulation medicine.anatomical_structure Endocrinology Chronic Disease biology.protein Tumor necrosis factor alpha Female |
| Popis: | Background: In the intestinal tract, the role of sympathetic neurotransmitters has been largely ignored in mucosal neuroimmunology. Aim: Our aim was to investigate the influence of the sympathetic microenvironment on the mucosal interplay of tumour necrosis factor (TNF) and interleukin 6 (IL-6). Methods: Colon strips of normal and colitic BALB/c mice were superfused in vitro. Tissue was electrically stimulated to investigate the influence of endogenous norepinephrine (NE) on secretion of IL-6, with or without anti-TNF antibodies (anti-TNF) and adrenoceptor antagonists. IL-6 was secreted from macrophages. Results: Superfusion with anti-TNF stimulated IL-6 secretion in normal but not in colitic colon (p |
| Databáze: | OpenAIRE |
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