Moist-Retaining, Self-Recoverable, Bioadhesive, and Transparent in Situ Forming Hydrogels To Accelerate Wound Healing
| Autor: | Jun Li, Biao Cheng, Xiumei Mo, Xiaolong Li, Gong Chen, Jian-feng Pan, Fan Yu, Jia Liu, Cheng Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
In situ
Materials science Time Factors Biocompatibility Cell Survival Bioadhesive Injectable hydrogels Biocompatible Materials macromolecular substances 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Rats Sprague-Dawley Adhesives medicine Animals Regeneration General Materials Science Cell Proliferation Skin Chitosan Wound Healing integumentary system technology industry and agriculture Granulation tissue Water Humidity Hydrogels Starch 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure Wound area Self-healing hydrogels Granulation Tissue 0210 nano-technology Wound healing Biomedical engineering |
| Zdroj: | ACS applied materialsinterfaces. 12(2) |
| ISSN: | 1944-8252 |
| Popis: | In the management of accelerating wound healing, moist environments play an important role. Compared with other scaffolds of various forms, hydrogels can maintain a moist environment in the wound area. They are cross-linked hydrophilic polymeric networks that resemble natural soft tissues and extracellular matrices. Among them, injectable hydrogels have attracted great attention in wound repair, as they can be injected into irregular-shaped skin defects and formed in situ to shape the contour of different dimensions. The excellent compliance makes hydrogels easy to adapt to the wound under different conditions of skin movement. Here, we oxidized hydroxyethyl starch (O-HES) and modified carboxymethyl chitosan (M-CMCS) to fabricate an in situ forming hydrogel with excellent self-recoverable extensibility-compressibility, biocompatibility, biodegradability, and transparency for accelerating wound healing. The oxidation degree of O-HES was 74%. The amino modification degree of M-CMCS was 63%. M-CMCS/O-HES hydrogels were formed through the Schiff base reaction. The physicochemical properties of M-CMCS/O-HES hydrogels with various ratios were investigated, and M-CMCS/O-HES hydrogel with a volume ratio of 5:5 exhibited appropriate gelation time, notable water-retaining capacity, self-recoverable conformal deformation, suitable biodegradability, and good biocompatibility for wound-healing application. Then, skin wound-healing experimental studies were carried out in Sprague-Dawley rats with full-thickness skin defects. Significant outcomes were achieved in the M-CMCS/O-HES hydrogel-treated group including higher wound closure percentage, more granulation tissue formation, faster epithelialization, and decreased collagen deposition. These findings demonstrate that using the obtained M-CMCS/O-HES hydrogels is a promising therapeutic strategy for wound healing. |
| Databáze: | OpenAIRE |
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