Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?
| Autor: | Rossella Di Raimo, Stefano Fais, Hiroaki Murata, Fabrizio Carta, Katsuyuki Kusuzaki, Claudiu T. Supuran, Mariantonia Logozzi, Elisabetta Iessi, Takao Matsubara |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Extracellular nanovesicles medicine.medical_treatment Photodynamic therapy photodynamic molecules Review exosomes Biology 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Drug Discovery medicine Extracellular acridine orange Humans Cytotoxic T cell Pharmacology Biological Products Photosensitizing Agents lcsh:RM1-950 Cancer General Medicine Photosensitizing Agent medicine.disease Microvesicles 030104 developmental biology lcsh:Therapeutics. Pharmacology Photochemotherapy 030220 oncology & carcinogenesis Drug delivery Immunology Systemic administration Cancer research Nanoparticles |
| Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 908-916 (2017) Journal of Enzyme Inhibition and Medicinal Chemistry |
| ISSN: | 1475-6374 1475-6366 |
| Popis: | Photodynamic molecules represent an alternative approach for cancer therapy for their property (i) to be photo-reactive; (ii) to be not-toxic for target cells in absence of light; (iii) to accumulate specifically into tumour tissues; (iv) to be activable by a light beam only at the tumour site and (v) to exert cytotoxic activity against tumour cells. However, to date their clinical use is limited by the side effects elicited by systemic administration. Extracellular vesicles are endogenous nanosized-carriers that have been recently introduced as a natural delivery system for therapeutic molecules. We have recently shown the ability of human exosomes to deliver photodynamic molecules. Therefore, this review focussed on extracellular vesicles as a novel strategy for the delivery of photodynamic molecules at cancer sites. This completely new approach may enhance the delivery and decrease the toxicity of photodynamic molecules, therefore, represent the future for photodynamic therapy for cancer treatment. |
| Databáze: | OpenAIRE |
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