The Risk for Medial Arterial Calcification in CKD

Autor: Nada Abou Hassan, Ellen T. D'Orsi, Carl J. D'Orsi, W. Charles O'Neill
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Tunica media
medicine.medical_specialty
Georgia
Epidemiology
urologic and male genital diseases
Critical Care and Intensive Care Medicine
Kidney
Risk Assessment
Severity of Illness Index
Risk Factors
Internal medicine
Diabetes mellitus
Severity of illness
medicine
Odds Ratio
Prevalence
Humans
Breast
Risk factor
Vascular Calcification
Retrospective Studies
Medial arterial calcification
Transplantation
Chi-Square Distribution
business.industry
Retrospective cohort study
Odds ratio
Original Articles
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
Surgery
medicine.anatomical_structure
Cross-Sectional Studies
Logistic Models
Nephrology
Chronic Disease
Multivariate Analysis
Cardiology
Kidney Failure
Chronic
Female
Kidney Diseases
Risk assessment
business
Tunica Media
Glomerular Filtration Rate
Mammography
Popis: CKD is a risk factor for medial artery calcification, but the CKD stage at which this risk begins is unknown. Because breast arterial calcification (BAC) is a marker of generalized medial arterial calcification, mammography was used to detect medial arterial calcification in women with different CKD stages.This was a retrospective, cross-sectional study of women with and without CKD matched for age and diabetes and identified from mammograms obtained in 2006-2011. BAC was scored as present or absent per visual inspection.A total of 146 women with stage 3 CKD and 54 with stage 4/5 CKD were identified. An additional 21 patients with ESRD were identified and added to a previous cohort of 71 patients. Mean age was 64 years for CKD 3, 63 for CKD 4, and 59 for ESRD. Half of each group had diabetes. Compared with controls, the odds ratios for BAC were 1.44 in CKD 3 (95% confidence interval [CI], 0.82-2.53), 2.69 in CKD 4 (95% CI, 1.14-6.33), and 7.19 in ESRD (95% CI, 3.77-13.7) and did not differ with diabetic status or race. In a multivariable logistic model, age (P0.001) and estimated GFR (P=0.005) were independent predictors of BAC. The odds ratio for BAC increased 4% for each milliliter per minute per 1.73 m(2) decrease in estimated GFR. The prevalence of BAC in CKD was increased in each decade of age over 49 years.CKD is an independent risk factor for medial arterial calcification.
Databáze: OpenAIRE
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