The Risk for Medial Arterial Calcification in CKD
Autor: | Nada Abou Hassan, Ellen T. D'Orsi, Carl J. D'Orsi, W. Charles O'Neill |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Tunica media
medicine.medical_specialty Georgia Epidemiology urologic and male genital diseases Critical Care and Intensive Care Medicine Kidney Risk Assessment Severity of Illness Index Risk Factors Internal medicine Diabetes mellitus Severity of illness medicine Odds Ratio Prevalence Humans Breast Risk factor Vascular Calcification Retrospective Studies Medial arterial calcification Transplantation Chi-Square Distribution business.industry Retrospective cohort study Odds ratio Original Articles Middle Aged medicine.disease female genital diseases and pregnancy complications Surgery medicine.anatomical_structure Cross-Sectional Studies Logistic Models Nephrology Chronic Disease Multivariate Analysis Cardiology Kidney Failure Chronic Female Kidney Diseases Risk assessment business Tunica Media Glomerular Filtration Rate Mammography |
Popis: | CKD is a risk factor for medial artery calcification, but the CKD stage at which this risk begins is unknown. Because breast arterial calcification (BAC) is a marker of generalized medial arterial calcification, mammography was used to detect medial arterial calcification in women with different CKD stages.This was a retrospective, cross-sectional study of women with and without CKD matched for age and diabetes and identified from mammograms obtained in 2006-2011. BAC was scored as present or absent per visual inspection.A total of 146 women with stage 3 CKD and 54 with stage 4/5 CKD were identified. An additional 21 patients with ESRD were identified and added to a previous cohort of 71 patients. Mean age was 64 years for CKD 3, 63 for CKD 4, and 59 for ESRD. Half of each group had diabetes. Compared with controls, the odds ratios for BAC were 1.44 in CKD 3 (95% confidence interval [CI], 0.82-2.53), 2.69 in CKD 4 (95% CI, 1.14-6.33), and 7.19 in ESRD (95% CI, 3.77-13.7) and did not differ with diabetic status or race. In a multivariable logistic model, age (P0.001) and estimated GFR (P=0.005) were independent predictors of BAC. The odds ratio for BAC increased 4% for each milliliter per minute per 1.73 m(2) decrease in estimated GFR. The prevalence of BAC in CKD was increased in each decade of age over 49 years.CKD is an independent risk factor for medial arterial calcification. |
Databáze: | OpenAIRE |
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