A retrospective study of daptomycin use in a Paris teaching-hospital
| Autor: | C. Dumortier, C. Esquirol, Laurence Armand-Lefevre, P. Arnaud, E. Papy, P. Longuet, Christophe Rioux, Sylvain Diamantis, N. Bourgeois-Nicolaos, Michel Wolff, J.-C. Lucet, F. Marc |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Paris medicine.medical_specialty medicine.drug_class Antibiotics Inappropriate Prescribing Drug Prescriptions Teaching hospital Young Adult Daptomycin Internal medicine Humans Medicine Endocarditis Medical prescription Hospitals Teaching Osteitis Aged Retrospective Studies Aged 80 and over Cross Infection business.industry Drug Resistance Microbial Retrospective cohort study Bacterial Infections Middle Aged Staphylococcal Infections biochemical phenomena metabolism and nutrition medicine.disease Drug Utilization Anti-Bacterial Agents Surgery Treatment Outcome Infectious Diseases Infective endocarditis Practice Guidelines as Topic Drug Therapy Combination Female Guideline Adherence business medicine.drug |
| Zdroj: | Médecine et Maladies Infectieuses. 44:25-31 |
| ISSN: | 0399-077X |
| DOI: | 10.1016/j.medmal.2013.11.002 |
| Popis: | Objective We retrospectively studied daptomycin use during 2010 at the Bichat-Claude-Bernard teaching-hospital (Paris) to observe the evolution of daptomycin prescriptions. Patients and methods Twenty-one patients were included and several parameters were documented: site of infection, bacterial species involved, reason for daptomycin use, dose and clinical outcome. Results Ninety-five percent of daptomycin prescritions were off-label and most did not comply with local guidelines. Fifteen of the 21 patients were cured (71%), including 9 patients of the 12 with off-label and off-local recommendation prescriptions (75%). Osteitis and Enterococcus spp endocarditis were the new indications. Daptomycin was increasingly used at higher doses: 52% of our patients were given doses above 6 mg/kg. Staphylococcus spp . was the most frequent pathogen responsible for infection is our patients, followed by Enterococcus spp . Conclusion Daptomycin use is likely to evolve because of its effectiveness in the treatment of osteitis, left-sided and Enterococcus spp . infective endocarditis. It is generally used at higher doses, which are well tolerated. However, therapeutic monitoring needs to be developed. The antibiotic commission of our hospital gave new recommendations for daptomycin use in 2011. |
| Databáze: | OpenAIRE |
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