The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)
| Autor: | Kelsey Gasior, Nikki J. Wagner, Alyson G. Wilson, Marlene L. Hauck, Jhon Cores, Rose Caspar, Sudin Bhattacharya |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell type Epithelial-Mesenchymal Transition emt Population Breast Neoplasms epithelial colon carcinoma Adenocarcinoma mesenchymal tgf-β 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cell Movement Transforming Growth Factor beta TGF beta signaling pathway Cell Adhesion Tumor Cells Cultured Humans breast carcinoma Epithelial–mesenchymal transition lcsh:QH573-671 education Cell adhesion education.field_of_study lcsh:Cytology Chemistry Mesenchymal stem cell cellular adhesion Cell Biology Cell biology 030104 developmental biology Cell culture 030220 oncology & carcinogenesis Female Colorectal Neoplasms Signal Transduction Research Article Transforming growth factor |
| Zdroj: | Cell Adhesion & Migration, Vol 13, Iss 1, Pp 63-75 (2019) Cell Adhesion & Migration |
| ISSN: | 1933-6926 1933-6918 |
| Popis: | The epithelial mesenchymal transition (EMT) is one step in the process through which carcinoma cells metastasize by gaining the cellular mobility associated with mesenchymal cells. This work examines the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells. While the SW480 population revealed an intermediate state between the epithelial and mesenchymal states, the MC7 cells exhibited highly adhesive behavior. However, for both cell lines, an exogenous TGF-β signal and a reduction in cellular confluence can push a subgroup of the population towards the mesenchymal phenotype. Together, these results highlight that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|