Vibrio cholerae hemolysin is apoptogenic to peritoneal B-1a cells but its oligomer shepherd the cells for IgA response
| Autor: | Tapas Biswas, Gayatri Mukherjee, Amlan Biswas, Kalyan K. Banerjee |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Cell signaling
Immunology Cell Apoptosis Biology medicine.disease_cause Oligomer Microbiology Hemolysin Proteins Mice chemistry.chemical_compound Immune system Bacterial Proteins medicine Animals RNA Messenger Protein Structure Quaternary Vibrio cholerae Molecular Biology Mice Inbred BALB C Interleukin-6 Hemolysin Toll-Like Receptor 2 Immunoglobulin A Up-Regulation TLR2 medicine.anatomical_structure Immunoglobulin M chemistry Interleukin-5 Peritoneum |
| Zdroj: | Molecular Immunology. 45:266-270 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2007.04.024 |
| Popis: | Vibrio cholerae hemolysin (HlyA) can exist as a monomer with hemolytic activity and an oligomer that agglutinates erythrocytes. Biochemical differences accompanying the change in state of aggregation led us to weigh possible differences between the two forms from mucosal immunoregulation perspective. HlyA oligomer-treated murine B-1a cells up-regulated TLR2 and involved the signaling molecules MyD88, TRAF6 and NF-kappaB. The cells subsequently expressed IgM and IgA. HlyA monomer treatment although resulted in TLR2 up-regulation, could not induce these effects. Apoptosis was detected in majority of the monomer-treated cells that involved caspase-9 and caspase-3. This study shows for the first time that two forms of the same protein could drive the host immune cell to two different outcomes, one of death and the other towards activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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