Changes in the vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and c-reactive protein following administration of aqueous extract of piper sarmentosum on experimental rabbits fed with cholesterol diet
| Autor: | Zaiton Zakaria, Nor Anita Mm Nordin, Faizah Othman, Srijit Das, Adel A. Amran, Hesham M. Al-Mekhlafi |
|---|---|
| Přispěvatelé: | University of Malaya [Kuala Lumpur, Malaisie] |
| Rok vydání: | 2010 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Clinical Biochemistry MESH: Rabbits 030204 cardiovascular system & hematology Antioxidants law.invention Cholesterol Dietary chemistry.chemical_compound 0302 clinical medicine Blood serum Endocrinology law [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Animals MESH: Cholesterol Dietary lcsh:RC620-627 2. Zero hunger 0303 health sciences biology Cell adhesion molecule MESH: Piper MESH: Hypercholesterolemia Intercellular Adhesion Molecule-1 3. Good health MESH: Plant Leaves lcsh:Nutritional diseases. Deficiency diseases C-Reactive Protein Biochemistry MESH: Phytotherapy Rabbits Lipidology medicine.medical_specialty Clinical chemistry Hypercholesterolemia MESH: Plant Extracts Vascular Cell Adhesion Molecule-1 Piper sarmentosum 03 medical and health sciences Internal medicine MESH: C-Reactive Protein medicine Animals 030304 developmental biology Biochemistry medical Cholesterol Plant Extracts MESH: Intercellular Adhesion Molecule-1 Research Biochemistry (medical) C-reactive protein MESH: Antioxidants MESH: Vascular Cell Adhesion Molecule-1 biology.organism_classification MESH: Male Plant Leaves chemistry biology.protein Phytotherapy Piper |
| Zdroj: | Lipids in Health and Disease Lipids Health Dis Lipids Health Dis, 2011, 10, pp.2. ⟨10.1186/1476-511X-10-2⟩ Lipids in Health and Disease, Vol 10, Iss 1, p 2 (2011) |
| ISSN: | 1476-511X |
| DOI: | 10.1186/1476-511X-10-2⟩ |
| Popis: | Background Inflammation process plays an important role in the development of atherosclerosis. Hypercholesterolemia is one of the major risk factors for atherosclerosis. The present study aimed to evaluate the effect of aqueous extract of Piper sarmentosum (P.s) on inflammatory markers like vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and C-reactive protein (CRP). Methods Forty two male New Zealand white rabbits were divided equally into seven groups; (i) C- control group fed normal rabbit chow (ii) CH- cholesterol diet (1%cholesterol) (iii) X1- 1% cholesterol with water extract of P.s (62.5 mg/kg) (iv) X2- 1% cholesterol with water extract of P.s (125 mg/kg (v) X3- 1% cholesterol with water extract of P.s (250 mg/kg) (vi) X4- 1% cholesterol with water extract of P.s (500 mg/kg) and (vii) SMV group fed with 1% cholesterol supplemented with simvistatin drug (1.2 mg/kg). All animals were treated for 10 weeks. Blood serum was taken for observing the inflammatory markers at the beginning and end of the experiment. Results Rabbits fed with 1% cholesterol diet (CH) showed significant increase in the level of VCAM-1, ICAM-1 and CRP compared to the C group. The levels of VCAM-1, ICAM-1 and CRP in the 1% cholesterol group and supplemented with P.s (500 mg/kg) were significantly reduced compared to the cholesterol group. Similar results were also reported with simvistatin group. Conclusion These results suggest that the supplementation of Piper sarmentosum extract could inhibit inflammatory markers which in turn could prevent atherosclerosis. |
| Databáze: | OpenAIRE |
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