Synthesis of 3′-O2-(Azaheterocycle)-Thymidines
| Autor: | Jacques Lebreton, Didier Dubreuil, Michel Evers, Guillaume Prestat, Ané Adjou, Jean Paul Pradere, Yvette Henin |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Aza Compounds
Magnetic Resonance Spectroscopy Anti-HIV Agents Chemistry RNA-Directed DNA Polymerase General Medicine Nuclear magnetic resonance spectroscopy Cytotoxicity Tests Immunologic Biochemistry Combinatorial chemistry Nucleophile Electrophile HIV-1 Genetics Molecular Medicine Reactivity (chemistry) Lymphocytes Cells Cultured Thymidine |
| Zdroj: | Nucleosides, Nucleotides and Nucleic Acids. 19:735-748 |
| ISSN: | 1532-2335 1525-7770 |
| DOI: | 10.1080/15257770008035021 |
| Popis: | The synthesis of 3'-O2-(azaheterocycle)-thymidines is presented from 1-thia-3-aza- 1,3-butadiene precursors (N-thioacylamidines). A variety of heterocycles is accessible using the dienic, the electrophilic or the nucleophilic reactivity of these thia-azabutadiene systems. 3'-O2-(azaheterocycle)-thymidine analogues are regarded as potential substrates to interfere with the DNA-polymerization process. |
| Databáze: | OpenAIRE |
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