Hemizygosity Enhances Purifying Selection: Lack of Fast-Z Evolution in Two Satyrine Butterflies
| Autor: | Marion Ballenghien, Nicolas Faivre, Benoit Nabholz, Nicolas Galtier, Marjolaine Rousselle |
|---|---|
| Přispěvatelé: | Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226 |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine X Chromosome Hemizygosity Biology [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics Phylogenetics and taxonomy Y chromosome Evolution Molecular sex-biased expression transcriptomics 03 medical and health sciences Negative selection Molecular evolution Y Chromosome [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Genetics Animals fast-Z effect Selection Genetic Ecology Evolution Behavior and Systematics Hemizygote Z chromosome Polymorphism Genetic [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] Autosome Nymphalidae Chromosomes Insect sex-chromosome evolution Lepidoptera Fixation (population genetics) 030104 developmental biology Evolutionary biology Female Butterflies Heterogametic sex Research Article |
| Zdroj: | Genome Biology and Evolution Genome Biology and Evolution, 2016, 8 (10), pp.3108-3119. ⟨10.1093/gbe/evw214⟩ Genome Biology and Evolution, Society for Molecular Biology and Evolution, 2016, 8 (10), pp.3108-3119. ⟨10.1093/gbe/evw214⟩ |
| ISSN: | 1759-6653 |
| DOI: | 10.1093/gbe/evw214 |
| Popis: | International audience; The fixation probability of a recessive beneficial mutation is increased on the X or Z chromosome, relative to autosomes, because recessive alleles carried by X or Z are exposed to selection in the heterogametic sex. This leads to an increased dN/dS ratio on sex chromosomes relative to autosomes, a pattern called the "fast-X" or "fast-Z" effect. Besides positive selection, the strength of genetic drift and the efficacy of purifying selection, which affect the rate of molecular evolution, might differ between sex chromosomes and autosomes. Disentangling the complex effects of these distinct forces requires the genome-wide analysis of polymor-phism, divergence and gene expression data in a variety of taxa. Here we study the influence of hemizygosity of the Z chromosome in Maniola jurtina and Pyronia tithonus, two species of butterflies (Lepidoptera, Nymphalidae, Satyrinae). Using transcriptome data, we compare the strength of positive and negative selection between Z and autosomes accounting for sex-specific gene expression. We show that M. jurtina and P. tithonus do not experience a faster, but rather a slightly slower evolutionary rate on the Z than on autosomes. Our analysis failed to detect a significant difference in adaptive evolutionary rate between Z and autosomes, but comparison of male-biased, unbiased and female-biased Z-linked genes revealed an increased efficacy of purifying selection against recessive deleterious mutations in female-biased Z-linked genes. This probably contributes to the lack of fast-Z evolution of satyrines. We suggest that the effect of hemizygosity on the fate of recessive deleterious mutations should be taken into account when interpreting patterns of molecular evolution in sex chromosomes vs. autosomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|