Effect of interleukin-2 on some micronutrients during adoptive immunotherapy for various cancers
| Autor: | D P Petrylak, Herman Baker, B DeAngelis, Oscar Frank, Elliott R. Baker, S L Marcus, P H Wiernik, J P Dutcher |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Riboflavin Immunotherapy Adoptive chemistry.chemical_compound Nutrient Neoplasms Internal medicine medicine Humans Inositol Nutrition and Dietetics Carotene Vitamins Immunotherapy Middle Aged Micronutrient Endocrinology Cytokine chemistry Interleukin-2 Female |
| Zdroj: | Journal of the American College of Nutrition. 11:482-486 |
| ISSN: | 1541-1087 0731-5724 |
| Popis: | In 20 patients, we investigated the effect of interleukin-2 (IL-2) treatment during adoptive immunotherapy for various cancers on circulating levels of: thiamin; biotin; folate; pantothenate; riboflavin; nicotinate; vitamins A, B6, B12 and E; carotenes; free and total cholines; inositol; and free and total carnitines. Of the above micronutrients, only vitamins A, B6, B12, inositol, carotenes and folate varied markedly from normal levels (pre IL-2 exposure) to abnormal levels (post IL-2). Following IL-2 exposure, every patient's B12 level was significantly elevated; 50% of the levels were abnormally increased above 1000 pg/ml. Extreme significant elevations of inositol were also seen in 90% of the patients. In contrast, IL-2 exposure depressed normal vitamins A, B6, carotene, and folate levels to subnormal; 90% of the patients became B6 hypovitaminemic; 60% for vitamin A, 80% for carotene, and 45% for folate. Other micronutrients tested showed no clear deviations from normal levels post IL-2 exposure. Some reasons for micronutrient variations are discussed. |
| Databáze: | OpenAIRE |
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