Relationship between Exhaled Nitric Oxide Measured by Two Offline Methods and Bronchial Hyperresponsiveness in Japanese Adults with Asthma
| Autor: | Hidenori Tanimoto, Sonoko Morita, Takahiro Tsuburai, Naomi Tsurikisawa, Masami Taniguchi, Yuma Fukutomi, Kunihiko Ikehara, Chiyako Oshikata, Kazuo Akiyama, Hideki Hasunuma, Hiroshi Kanegae, Yasushi Ishimaru, Emiko Ono, Kiyoshi Sekiya, Mamoru Otomo, Yuji Maeda |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male lcsh:Immunologic diseases. Allergy Spirometry bronchial hyperresponsiveness medicine.medical_specialty Nitric Oxide Gastroenterology Bronchial Provocation Tests Adrenal Cortex Hormones Enos Internal medicine Administration Inhalation medicine Humans offline method Immunology and Allergy Asthmatic patient Outpatient clinic Aged Asthma biology medicine.diagnostic_test business.industry General Medicine Middle Aged asthma biology.organism_classification medicine.disease Breath Tests Bronchial hyperresponsiveness Immunology Exhaled nitric oxide exhaled nitric oxide Population study Female Bronchial Hyperreactivity lcsh:RC581-607 business |
| Zdroj: | Allergology International, Vol 57, Iss 3, Pp 223-229 (2008) |
| ISSN: | 1323-8930 |
| DOI: | 10.2332/allergolint.o-07-518 |
| Popis: | Background Exhaled nitric oxide (eNO) is a useful marker of eosinophilic airway inflammation in asthmatics. There have been no studies to show the relationship between eNO measured by offline methods and the degree of bronchial hyperresponsiveness in asthmatic patients treated with inhaled corticosteroids. Methods The study population comprised asthmatics at our outpatient clinic. We measured eNO levels by two methods ("eNOs" was measured with a Sievers kit; and "eNOc" was measured with a kit from the Center for Environmental Information Science, Japan). We also used spirometry to test bronchial hyperresponsiveness to acetylcholine (PC 20Ach ). Results We recruited 192 stable asthmatics. There was a significant relationship between eNOs and eNOc ( r = 0.919, p 20Ach levels were negatively correlated with eNOs or eNOc levels (eNOs, r = −0.31, p r = −0.23, p = 0.0013). We classified the subjects into two groups based on eNOs levels ((A) the subjects with high eNOs levels ( n = 92) and (B) the subjects with normal eNOs levels ( n = 100) ); logPC 20Ach was significantly correlated with eNOs ( r = −0.34, p = 0.001) or eNOc ( r = −0.28, p = 0.0075) but not correlated with %FEV 1 in (A), whereas logPC 20Ach was not significantly correlated with eNO but significantly correlated with %FEV 1 ( r = 0.33, p = 0.002) in (B). Conclusions Levels of eNOs and eNOc were correlated with the degree of bronchial hyperresponsiveness to acetylcholine in adult asthmatics treated with inhaled corticosteroids. Our findings suggest that offline monitoring of eNO will facilitate the management of bronchial asthma in patients treated with these drugs. |
| Databáze: | OpenAIRE |
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