Alcoholic Hepatitis: A Review
Autor: | Julia Shor, Gyongyi Szabo, Nooshin Hosseini |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Alcoholic liver disease Cirrhosis Kupffer Cells Alcoholic hepatitis Review Gastroenterology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine medicine Humans 030304 developmental biology 0303 health sciences business.industry Hepatitis Alcoholic General Medicine medicine.disease Prednisolone Hepatic stellate cell 030211 gastroenterology & hepatology Steatosis Inflammation Mediators business Reactive Oxygen Species medicine.drug |
Zdroj: | Alcohol Alcohol |
Popis: | Alcoholic liver disease (ALD) represents a spectrum of injury, ranging from simple steatosis to alcoholic hepatitis to cirrhosis. Regular alcohol use results in fatty changes in the liver which can develop into inflammation, fibrosis and ultimately cirrhosis with continued, excessive drinking. Alcoholic hepatitis (AH) is an acute hepatic inflammation associated with significant morbidity and mortality that can occur in patients with steatosis or underlying cirrhosis. The pathogenesis of ALD is multifactorial and in addition to genetic factors, alcohol-induced hepatocyte damage, reactive oxygen species, gut-derived microbial components result in steatosis and inflammatory cell (macrophage and neutrophil leukocyte) recruitment and activation in the liver. Continued alcohol and pro-inflammatory cytokines induce stellate cell activation and result in progressive fibrosis. Other than cessation of alcohol use, medical therapy of AH is limited to prednisolone in a subset of patients. Given the high mortality of AH and the progressive nature of ALD, there is a major need for new therapeutic intervention for this underserved patient population. |
Databáze: | OpenAIRE |
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