Core outcomes in neonatology: development of a core outcome set for neonatal research
| Autor: | Ben Wills-Eve, Laura Noakes, Chris Gale, Ginny Brunton, Caroline Lee-Davey, Angela Richard-Löndt, Elsa Afonso, Marian Knight, Julie Nycyk, Neena Modi, Iyad Al-Muzaffar, James Duffy, Anne Greenough, Neil Marlow, Jos M. Latour, James Webbe, Nigel J. Hall |
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| Přispěvatelé: | Mason Medical Research Foundation, Medical Research Council |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Biomedical Research evidence based medicine Gross motor skill Visual impairment Delphi method neonatology Pediatrics outcomes research Quality of life (healthcare) Outcome Assessment Health Care medicine Humans Neonatology Original Research business.industry Infant Obstetrics and Gynecology General Medicine Evidence-based medicine Clinical trial Family medicine Pediatrics Perinatology and Child Health 1114 Paediatrics and Reproductive Medicine Outcomes research medicine.symptom business |
| Zdroj: | Archives of Disease in Childhood. Fetal and Neonatal Edition |
| Popis: | BackgroundNeonatal research evaluates many different outcomes using multiple measures. This can prevent synthesis of trial results in meta-analyses, and selected outcomes may not be relevant to former patients, parents and health professionals.ObjectiveTo define a core outcome set (COS) for research involving infants receiving neonatal care in a high-income setting.DesignOutcomes reported in neonatal trials and qualitative studies were systematically reviewed. Stakeholders were recruited for a three-round international Delphi survey. A consensus meeting was held to confirm the final COS, based on the survey results.ParticipantsFour hundred and fourteen former patients, parents, healthcare professionals and researchers took part in the eDelphi survey; 173 completed all three rounds. Sixteen stakeholders participated in the consensus meeting.ResultsThe literature reviews identified 104 outcomes; these were included in round 1. Participants proposed 10 additional outcomes; 114 outcomes were scored in rounds 2 and 3. Round 1 scores showed different stakeholder groups prioritised contrasting outcomes. Twelve outcomes were included in the final COS: survival, sepsis, necrotising enterocolitis, brain injury on imaging, general gross motor ability, general cognitive ability, quality of life, adverse events, visual impairment/blindness, hearing impairment/deafness, retinopathy of prematurity and chronic lung disease/bronchopulmonary dysplasia.Conclusions and relevanceA COS for clinical trials and other research studies involving infants receiving neonatal care in a high-income setting has been identified. This COS for neonatology will help standardise outcome selection in clinical trials and ensure these are relevant to those most affected by neonatal care. |
| Databáze: | OpenAIRE |
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