Raised Interleukin-6 Levels in Obese Patients
| Autor: | Lev Greemberg, Simon Gelman, Leonid Roytblat, Yoram Shapira, Allan Fisher, Maxim Rachinsky, Amos Douvdevani |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Hypoxemia Oxygen Consumption Endocrinology Internal medicine Healthy volunteers Humans Medicine Obesity Interleukin 6 Oxygen saturation (medicine) Obesity hypoventilation syndrome Sleep Apnea Obstructive biology Interleukin-6 business.industry Public Health Environmental and Occupational Health Lipid metabolism Hypoventilation Syndrome Middle Aged medicine.disease Obstructive sleep apnea biology.protein Female medicine.symptom business Body mass index Food Science |
| Zdroj: | Obesity Research. 8:673-675 |
| ISSN: | 1071-7323 |
| DOI: | 10.1038/oby.2000.86 |
| Popis: | Objective: Obese patients demonstrate a variety of biochemical, metabolic, and pulmonary abnormalities. Inflammatory mediators such as tumor necrosis factor-α and interleukin-6 (IL-6) may have a direct effect on glucose and lipid metabolism. Hypoxemia in itself induces release of IL-6. The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of 35 kg/m2) and 12 healthy women. Results: The results demonstrate statistically significant differences in serum IL-6 levels between the control group (1.28 ± 0.85 pg/mL) and obese patients without OSAS (7.69 ± 5.06 pg/mL, p < 0.05) and with OSAS (5.58 ± 0.37 pg/mL, p < 0.0005). In the patients with OHS, IL-6 concentrations were highest (43.13 ± 24.27 pg/mL). Discussion: We conclude that serum IL-6 is increased in obese patients. The highest IL-6 levels were found in the patients with OHS. |
| Databáze: | OpenAIRE |
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