PET imaging of bacterial infections with fluorine-18-labeled maltohexaose

Autor: Xiaojian Wang, Niren Murthy, Vernon M. Camp, Lawrence E. Williams, Mark M. Goodman, Seungjun Lee, W. Robert Taylor, Daiana Weiss, Malveaux Eugene, Kiyoko Takemiya, Xuli Feng, Xinghai Ning, Mohammad A. Rafi, Wonewoo Seo
Rok vydání: 2014
Předmět:
Fluorine Radioisotopes
positron emission tomography
Oligosaccharides
Drug resistance
Catalysis
Article
In vivo
medicine
Animals
maltohexaose
radiochemistry
Escherichia coli Infections
Fluorodeoxyglucose
Colony-forming unit
screening and diagnosis
biology
medicine.diagnostic_test
Molecular Structure
Chemistry
Prevention
fungi
Organic Chemistry
food and beverages
General Chemistry
Pet imaging
General Medicine
maltodextrin transporters
biology.organism_classification
Orders of magnitude (mass)
Rats
4.1 Discovery and preclinical testing of markers and technologies
Detection
Infectious Diseases
Biochemistry
bacterial infections
Positron emission tomography
Positron-Emission Tomography
Chemical Sciences
Biomedical Imaging
Infection
Bacteria
medicine.drug
4.2 Evaluation of markers and technologies
Zdroj: Angewandte Chemie (International ed. in English), vol 53, iss 51
Popis: A positron emission tomography (PET) tracer composed of (18)F-labeled maltohexaose (MH(18)F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ((18)FDG). MH(18)F can detect early-stage infections composed of as few as 10(5) E. coli colony-forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH(18)F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.
Databáze: OpenAIRE
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