Plasma concentrations of transthyretin in older Sardinians including centenarians
| Autor: | Luca Deiana, Ciriaco Carru, Salvatore Sotgia, Sara Pasella, Elisabetta Canu, Marta Deiana, Andrea Mannu, Angela Baralla, Arduino A. Mangoni, Simone Dore, Giovanni Sotgiu, Sara Pinna, Angelo Zinellu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine endocrine system Aging medicine.medical_specialty Age and sex 01 natural sciences 03 medical and health sciences Elisa kit Sex Factors Internal medicine medicine Humans Prealbumin Aged Aged 80 and over Fetus biology Geriatrics gerontology business.industry Sardinian population Age Factors Healthy subjects nutritional and metabolic diseases Middle Aged 0104 chemical sciences 010404 medicinal & biomolecular chemistry Transthyretin 030104 developmental biology Endocrinology Italy Plasma concentration biology.protein Female Geriatrics and Gerontology business |
| Zdroj: | Aging Clinical and Experimental Research. 28:77-82 |
| ISSN: | 1720-8319 |
| Popis: | Plasma concentrations of transthyretin (TTR), a negative acute-phase protein, can be influenced by many factors including aging. Under physiological circumstances, TTR concentrations are very low in the fetus, increase slowly after birth up to the fifth decade and, then, decrease slowly. Some studies have shown sex-related differences up to about 70 years, when the differences disappear. The aim of this study was to evaluate the change in TTR concentrations in healthy males and females aged more than sixty, including numerous centenarians living in Sardinia, a large Italian island located in the Mediterranean Sea. The study sample consisted of 211 healthy subjects grouped by age and sex (male/female ratio: 1:1). Plasma TTR was assessed using a non-competitive enzyme immunoassay (ELISA Assaypro LLC, prealbumin AssayMAX Human ELISA Kit). In subjects aged between 60 and 99 years, plasma TTR concentrations were higher compared to the reference ranges reported by CRM 470. Moreover, unlike other studies, sex-related differences in TTR concentrations were only observed in nonagenarians and centenarians. We hypothesize that there are TTR-related genetic differences between the Sardinian population and other Caucasian ethnic groups. Further studies and a larger sample are needed to confirm our hypothesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink