Synthesis of Polysubstituted Pyrroles through Electro-Oxidative Annulation of 1,3-Dicarbonyl Compounds and Primary Amines

Autor:	Mingteng Xiong, Yuanjiang Pan, Xiao Liang, Yifeng Zhou
Rok vydání:	2021
Předmět:	Oxidative Stress Annulation Primary (chemistry) 010405 organic chemistry Chemistry Organic Chemistry Pyrroles Amines 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	The Journal of Organic Chemistry. 86:4986-4993
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.0c02911
Popis:	Reported herein is a synthetic method of polysubstituted pyrroles from easily available materials, 1,3-dicarbonyl compounds and primary amines, via electro-oxidative intermolecular annulation. Under similar conditions, enamines are also converted smoothly into desired products, indicating that in situ formed enamines are crucial intermediates for the first transformation. Neither transition-metal salts nor harsh conditions are required to facilitate the dehydrocyclization process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f29d1eef43d5eed8192488fd97e2b54 https://doi.org/10.1021/acs.joc.0c02911 Zobrazit plný text záznamu