Sex-related differences in cardiovascular disease risk profile in children and adolescents with type 1 diabetes

Autor: Tadej Battelino, Urh Groselj, Darja Smigoc Schweiger
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Male
cardiovascular risk factors
endocrine system diseases
type 1 diabetes
otroci
Blood Pressure
Coronary Artery Disease
Review
Disease
sladkorna bolezen tipa 1
gender
Medicine
adolescents
Biology (General)
Child
Spectroscopy
mladostniki
blood pressure
General Medicine
Computer Science Applications
Chemistry
Hypertension
Female
medicine.symptom
endocrine system
hiperglikemija
infekcijske bolezni
Adolescent
dislipidemija
QH301-705.5
spol
tveganje za srčno-žilna obolenja
Catalysis
smoking
Inorganic Chemistry
Sex Factors
children
Environmental health
Diabetes mellitus
kajenje
Humans
sex
Obesity
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
Dyslipidemias
Glycemic
Type 1 diabetes
business.industry
udc:616.379
krvni tlak
Organic Chemistry
dyslipidemia
nutritional and metabolic diseases
Atherosclerosis
medicine.disease
Diabetes Mellitus
Type 1
Heart Disease Risk Factors
inflammation
Hyperglycemia
Relative risk
Albuminuria
hyperglycemia
Sedentary Behavior
business
Dyslipidemia
Zdroj: International journal of molecular sciences, vol. 22, no. 19, 10192, 2021.
International Journal of Molecular Sciences, Vol 22, Iss 10192, p 10192 (2021)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Cardiovascular disease (CVD) is the primary cause of higher and earlier morbidity and mortality in people with type 1 diabetes (T1D) compared to people without diabetes. In addition, women with T1D are at an even higher relative risk for CVD than men. However, the underlying pathophysiology is not well understood. Atherosclerotic changes are known to progress early in life among people with T1D, yet it is less clear when excess CVD risk begins in females with T1D. This review explores the prevalence of classical CVD risk factors (such as glycemic control, hypertension, dyslipidemia, obesity, albuminuria, smoking, diet, physical inactivity), as well as of novel biomarkers (such as chronic inflammation), in children and adolescents with T1D with particular regard to sex-related differences in risk profile. We also summarize gaps where further research and clearer clinical guidance are needed to better address this issue. Considering that girls with T1D might have a more adverse CVD risk profile than boys, the early identification of and sex-specific intervention in T1D would have the potential to reduce later CVD morbidity and excess mortality in females with T1D. To conclude, based on an extensive review of the existing literature, we found a clear difference between boys and girls with T1D in the presence of individual CVD risk factors as well as in overall CVD risk profiles; the girls were on the whole more impacted.
Databáze: OpenAIRE
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