Biomarkers of Ovarian Reserve
| Autor: | Wendy J. Kivens, William E. Roudebush, Jessica M. Mattke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Infertility
endocrine system endocrine system diseases media_common.quotation_subject Physiology Ovary Biology Bioinformatics Follicle-stimulating hormone FSH medicine Ovarian reserve Ovarian Reserve Menstrual cycle Original Research media_common Pharmacology lcsh:R5-920 AMH/MIS Biochemistry (medical) Oocyte medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Molecular Medicine Folliculogenesis inhibin-B lcsh:Medicine (General) Hormone |
| Zdroj: | Biomarker Insights, Vol 3, Pp 259-268 (2008) Biomarker Insights, Vol 3 (2008) Biomarker Insights |
| ISSN: | 1177-2719 |
| Popis: | The primary function of the female ovary is the production of a mature and viable oocyte capable of fertilization and subsequent embryo development and implantation. At birth, the ovary contains a finite number of oocytes available for folliculogenesis. This finite number of available oocytes is termed “the ovarian reserve”. The determination of ovarian reserve is important in the assessment and treatment of infertility. As the ovary ages, the ovarian reserve will decline. Infertility affects approximately 15%–20% of reproductive aged couples. The most commonly used biomarker assay to assess ovarian reserve is the measurement of follicle stimulating hormone (FSH) on day 3 of the menstrual cycle. However, anti-müllerian hormone and inhibin-B are other biomarkers of ovarian reserve that are gaining in popularity since they provide direct determination of ovarian status, whereas day 3 FSH is an indirect measurement. This review examines the physical tools and the hormone biomarkers used to evaluate ovarian reserve. |
| Databáze: | OpenAIRE |
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