[Elevated Lipoprotein(a) Cncentration and Presence of Subfractions of Small Dense Low Density Lipoproteins as Independent Factors of Risk of Ischemic Heart Disease]
Autor: | E. Utkina, Marat V. Ezhov, Olga I. Afanasieva, I. Yu. Adamova, N. Artemieva, S.N. Pokrovsky |
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Rok vydání: | 2017 |
Předmět: |
Male
medicine.medical_specialty Apolipoprotein B 030232 urology & nephrology Coronary Artery Disease 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum High-density lipoprotein Risk Factors Internal medicine Mole Blood plasma medicine Humans Aged biology Triglyceride business.industry Hypertriglyceridemia Lipoprotein(a) Middle Aged medicine.disease Lipoproteins LDL Endocrinology chemistry Apolipoprotein B-100 biology.protein lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine business |
Zdroj: | Kardiologiia. 56(6) |
ISSN: | 0022-9040 |
Popis: | To study relation of lipoproteina - Lp(a) and subfractional composition of apoB containing lipoproteins to the presence of ischemic heart disease (IHD). Manerial and methods. Parameters of lipid spectrum, Lp(a), and subfractions of apoB containing lipoproteins were determined in blood serum of 187 patients with known data of instrumental examination.Lp(a) concentration was not linked to any of risk factors, levels total cholesterol (TC), low and high density lipoprotein CH, and subfractions of lipoproteins. In total group triglyceride (TGG) level correlated with content of small dense LDL (sdLDL) (r=0.445,0.0001) and mean dimension of LDL particles (r=-0.424, p0.0001). This correlation was absent in the subgroup with Lp(a) more or equal 30 mg/dl and was strengthered among patients with normal Lp(a) level. In total group presence of IHD was associated with sex (r=0.325, p0.0001), Lp(a) concentration (r=0.271, p=0.0001), and level of triglycerides (r=0.159, p=0.030). In multiple regression analysis levels of TG, Lp(a) and sdLDL were selected as factors independently associated with presence of IHD. Detection of subfractions sdLDL2 mg/dl in blood plasma (atherogenic profile B), as well as lowering of concentration of large LDL subfractions significantly increased probability of IHD presence in patients with elevated Lp(a) concentration Lp(a) concentration.Lp(a) is an independent factor of risk of coronary atherosclerosis more significant than shifts in subfractional composition of apoB containing lipoproteins. In patients with Lp(a) concentration less or equal 30 mg/dl subfractions of sdLDL were directly related to TG. Level of sdLDL and large lipoproteins of intermediate density are directly related to the presence of IHD. Large LDL correlates with concentration of HDL DL C and probably is cardioprotective. sdLDL content2 mg/l or hypertriglyceridemia (TG1.7 mmol/l) significantly increase chances of detection of confirmed IHD in patients with elevated Lp(a). |
Databáze: | OpenAIRE |
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