Effect of Pretreatment with Toll‐like Receptor Agonists in a Mouse Model of Herpes Simplex Virus Type 1 Encephalitis
| Autor: | Yan Sergerie, Guy Boivin, Nicolas Boivin, Serge Rivest |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Lipopolysaccharides
Agonist Lipopolysaccharide medicine.drug_class Oligonucleotides Stimulation Herpesvirus 1 Human Pharmacology Biology medicine.disease_cause Antiviral Agents Virus Mice chemistry.chemical_compound medicine Animals Immunology and Allergy Encephalitis Viral Receptor Mice Inbred BALB C Toll-like receptor Drug Administration Routes Toll-Like Receptors Viral Load Olfactory Bulb Disease Models Animal Poly I-C Infectious Diseases Herpes simplex virus Gene Expression Regulation chemistry Immunology TLR4 Microglia |
| Zdroj: | The Journal of Infectious Diseases. 198:664-672 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/590671 |
| Popis: | Background. We evaluated the effect of pretreatment with Toll-like receptor (TLR) agonists in a mouse model of herpes simplex virus type 1 (HSV-1) encephalitis. Methods. BALB/c mice received a single intraperitoneal or intranasal injection of polyinosinic:polycytidylic acid (poly I:C), a TLR3 agonist; lipopolysaccharide (LPS), a TLR4 agonist; oligodeoxynucleotide (ODN), a TLR9 agonist; or control vehicle. Twenty-four hours later, animals were infected with 5000 plaque-forming units of HSV-1. Results. Mice that received intraperitoneal pretreatment with vehicle, LPS, and poly I:C had survival rates of 7%, 13%, and 56%, respectively, and mean life expectancies of 156.80 ± 9.56, 176.00 ± 9.24, and 213.00 ± 7.71 h, respectively (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|