Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells
| Autor: | Rocky S. Tuan, Caren E. Petrie Aronin |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Embryology
Population Clinical uses of mesenchymal stem cells Biology Regenerative medicine Immunomodulation Immune privilege Animals Humans Regeneration education Stem cell transplantation for articular cartilage repair Inflammation education.field_of_study Extracellular Matrix Proteins Regeneration (biology) Mesenchymal stem cell Cell Differentiation Mesenchymal Stem Cells General Medicine Genetic Therapy Cell biology Adult Stem Cells Immunology Cytokines Developmental Biology Adult stem cell Stem Cell Transplantation |
| Zdroj: | Birth defects research. Part C, Embryo today : reviews. 90(1) |
| ISSN: | 1542-9768 |
| Popis: | Adult mesenchymal stem cells (MSCs) include a select population of resident cells within adult tissues, which retain the ability to differentiate along several tissue-specific lineages under defined media conditions and have finite expansion potential in vitro. These adult progenitor populations have been identified in various tissues, but it remains unclear exactly what role both transplanted and native MSCs play in processes of disease and regeneration. Interestingly, increasing evidence reveals a unique antiinflammatory immunomodulatory phenotype shared among this population, lending support to the idea that MSCs play a central role in early tissue remodeling responses where a controlled inflammatory response is required. However, additional evidence suggests that MSCs may not retain infinite immune privilege and that the context with which these cells are introduced in vivo may influence their immune phenotype. Therefore, understanding this dynamic microenvironment in which MSCs participate in complex feedback loops acting upon and being influenced by a plethora of secreted cytokines, extracellular matrix molecules, and fragments will be critical to elucidating the role of MSCs in the intertwined processes of immunomodulation and tissue repair. |
| Databáze: | OpenAIRE |
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