| Autor: |
Pierre Carmona, Magnus Röding, Aila Särkkä, Christian von Corswant, Eva Olsson, Niklas Lorén |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Soft matter. 18(16) |
| ISSN: |
1744-6848 |
| Popis: |
Porous phase-separated ethylcellulose/hydroxypropylcellulose (EC/HPC) films are used to control drug transport from pharmaceutical pellets. The drug transport rate is determined by the structure of the porous films that are formed as water-soluble HPC leaches out. However, a detailed understanding of the evolution of the phase-separated structure in the films is lacking. In this work, we have investigated EC/HPC films produced by spin-coating, mimicking the industrial fluidized bed spraying. The aim was to investigate film structure evolution and coarsening kinetics during solvent evaporation. The structure evolution was characterized using confocal laser scanning microscopy and image analysis. The effect of the EC:HPC ratio (15 to 85 wt% HPC) on the structure evolution was determined. Bicontinuous structures were found for 30 to 40 wt% HPC. The growth of the characteristic length scale followed a power law |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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