Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state
| Autor: | Maritza Cavalcante Barbosa, Ieda Pereira de Souza, Alcínia Braga de Lima Arruda, Marilia Rocha Laurentino, Lilianne Brito da Silva Rocha, Ronaldo Pinheiro Gonçalves, Alice Maria Costa Martins, Juliane Almeida Moreira, Romélia Pinheiro Gonçalves, Amanda de Menezes Mota, Rosângela Pinheiro Gonçalves Machado |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Anemia Hemolysis chemistry.chemical_compound Internal medicine Lactate dehydrogenase Fetal hemoglobin medicine Outpatient clinic Sickle cell Biological markers Hemoglobina lcsh:RC633-647.5 business.industry lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease Sickle cell anemia Arginase Endocrinology Biochemistry chemistry Uric acid Original Article business |
| Zdroj: | Revista Brasileira de Hematologia e Hemoterapia Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC Revista Brasileira de Hematologia e Hemoterapia v.37 n.3 2015 Revista brasileira de hematologia e hemoterapia Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC Revista Brasileira de Hematologia e Hemoterapia, Vol 37, Iss 3, Pp 167-171 (2015) Revista Brasileira de Hematologia e Hemoterapia, Volume: 37, Issue: 3, Pages: 167-171, Published: JUN 2015 |
| ISSN: | 1806-0870 1516-8484 |
| Popis: | Objective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Brazil. The control group consisted of 20 hemoglobin AA individuals. The reticulocyte count was performed by an automated methodology, lac- tate dehydrogenase and uric acid were measured by spectrophotometry and arginase I by enzyme-linked immunosorbent assay (ELISA). The presence of Hb S was detected by high-performance liquid chromatography. The level of significance was set for a p -value |
| Databáze: | OpenAIRE |
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