Epithelial ovarian cancer and type of peritoneal insult: a case-control study
| Autor: | Olivia Lisa Dziadek, Pedro Beltran Morales-Ramirez, Maria P. Ruiz, Stacey Denise Algren |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Exploratory laparotomy medicine.medical_treatment Population Endometriosis Gastroenterology 03 medical and health sciences 0302 clinical medicine Postoperative Complications Risk Factors Internal medicine Diabetes mellitus medicine Appendectomy Humans Cholecystectomy Neoplasms Glandular and Epithelial education Aged Gynecology Ovarian Neoplasms education.field_of_study Laparotomy 030219 obstetrics & reproductive medicine Hysterectomy business.industry Case-control study Obstetrics and Gynecology Middle Aged medicine.disease Diverticulosis Diverticulum Reproductive Medicine 030220 oncology & carcinogenesis Case-Control Studies Population study Female Peritoneum business |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 205 |
| ISSN: | 1872-7654 |
| Popis: | Objective To evaluate the association between different types of peritoneal insults and the development of sporadic epithelial ovarian cancer (EOC) subtypes in the general population. Study design Hospital based case control study comparing sporadic cases of EOC with age matched control group between 2003 and 2008. Medical, surgical, and gynecological histories were compared between 208 women with histological diagnosis of EOC and 224 women in the control group matched for age at presentation for well woman examination. Results 18% patients in the study population and 5% patients in the control group had history of diverticulosis (OR 7.3, 95% CI 2.8–19.1). 10% patients in the study populations and 39% patients in the control group had history of diabetes mellitus (OR 0.41, 95% CI 0.23–0.75). Sub classification of EOC into type 1 and type 2 further revealed 12% patients (OR 0.44, 95% CI 0.22–0.87) in type 1 group, 35% patients (OR 0.43, 95% CI 0.27–0.69) in type 2 group, and 71% patients in the control group had no prior surgical history. Furthermore, 3% patients (OR 0.27; 95% CI 0.08–0.9) in the type 1 group, 48% patients (OR 2.0, CI 95% 1.24–3.24) in the type 2 group, and 41% patients in the control group had history of bilateral tubal ligation (BTL). Conclusion A significant association was found between diverticulosis, hysterectomy and endometriosis increasing the likelihood of type 1 EOC; while diverticulosis, exploratory laparotomy and hysterectomy increased the likelihood of type 2 EOC. BTL was significantly associated with decreasing the likelihood of type 1 EOC, but increasing the likelihood of type 2 EOC. Diabetes mellitus and no prior surgical history were found to significantly decrease the likelihood of all EOC. |
| Databáze: | OpenAIRE |
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