Mixed-Phenotype Acute Leukemia: Diagnostic Criteria and Pitfalls
| Autor: | Daniel F. Boyer, Nathan J. Charles |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Myeloid
Population Fusion Proteins bcr-abl Disease World Health Organization World health Translocation Genetic Pathology and Forensic Medicine Immunophenotyping Diagnosis Differential 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Biomarkers Tumor Humans education education.field_of_study Acute leukemia Mixed phenotype acute leukemia business.industry General Medicine Histone-Lysine N-Methyltransferase medicine.disease Prognosis Immunohistochemistry Leukemia Biphenotypic Acute Medical Laboratory Technology Leukemia medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Practice Guidelines as Topic business Myeloid-Lymphoid Leukemia Protein 030215 immunology |
| Zdroj: | Archives of pathologylaboratory medicine. 141(11) |
| ISSN: | 1543-2165 |
| Popis: | Mixed-phenotype acute leukemia (MPAL) is a heterogeneous category in the World Health Organization classification that comprises acute leukemias with discrete admixed populations of myeloid and lymphoid blasts (“bilineal”) or with extensive coexpression of lymphoid and myeloid markers in a single blast population (“biphenotypic”). Flow cytometric findings suggestive of MPAL are often met with consternation by pathologists and oncologists alike, owing to unfamiliarity with the disease and uncertainty about how MPAL fits into established paradigms for treatment of acute leukemia. The purpose of this review is to explain the diagnostic criteria for MPAL, summarize its biological and clinical features, and address common diagnostic pitfalls of these unusual leukemias. |
| Databáze: | OpenAIRE |
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