An experimental study of cardiac natriuretic peptides as markers of development of congestive heart failure
| Autor: | O Djøseland, Christian Hall, B. E. Karlberg, Randi Furseth Klinge, M. E. Hystad, A Aakvaag, John Kjekshus |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Pacemaker Artificial medicine.medical_specialty Epinephrine Heart disease Swine medicine.drug_class Clinical Biochemistry Norepinephrine Atrial natriuretic peptide Internal medicine Natriuretic Peptide Brain Renin Natriuretic peptide Animals Medicine Protein Precursors Pulmonary wedge pressure Aldosterone Heart Failure Endothelin-1 business.industry Angiotensin II Myocardium Central venous pressure General Medicine Brain natriuretic peptide medicine.disease Preload Endocrinology Heart failure cardiovascular system Cardiology Female business Atrial Natriuretic Factor Biomarkers |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 58:683-691 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/00365519850186120 |
| Popis: | The use of cardiac peptide measurements as possible diagnostic tools in congestive heart failure has been extensively discussed in the recent literature. Therefore, the aim of this study was to establish a model of experimental chronic heart failure, and thereby perform a comparative study of secretion and circulating levels of the cardiac peptides atrial natriuretic peptide (ANP), N-terminal proatrial natriuretic peptide (N-terminal proANP) and brain natriuretic peptide (BNP) during evolving heart failure. Chronic heart failure was induced in seven pigs by rapid left atrial pacing for three weeks. The effects of failure induction were documented 24 h after pacemaker deactivation. Hemodynamic indices of cardiac preload, like pulmonary capillary wedge pressure (PCWP) and right atrial pressure (RAP), were all considerably increased compared to sham operated controls. Likewise, plasma endothelin-L, noradrenaline, renin activity, aldosterone and angiotensin II were all markedly increased. Heart failure was accompanied by significant increases in both estimated cardiac secretory rate and plasma concentrations of all three cardiac peptides, significantly correlated to the PCWP. The directional changes during evolving heart failure were similar, although the percentage increase in plasma BNP was much larger than for ANP and N-terminal proANP. In absolute molar terms, however, the BNP concentration changes were minor compared to those of the other two peptides. The larger percentage increase of BNP might indicate its superiority as a marker of heart failure development, provided a functional assay suitable for clinical use can be designed for a peptide circulating in this low concentration range. |
| Databáze: | OpenAIRE |
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