Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy

Autor:	Sandra Elizabeth Guerra-Palomares, Andreu Comas-García, Christian A. García-Sepúlveda, Daniel E. Noyola, J. S. Rodríguez-Cuevas, A. Benítez-Sánchez, Diana Lorena Alvarado-Hernández, T. Rosales-Saavedra
Rok vydání:	2016
Předmět:	Adult 0301 basic medicine Human cytomegalovirus Adolescent Genotype medicine.medical_treatment Immunology Population Cytomegalovirus HLA-C Antigens Hematopoietic stem cell transplantation 03 medical and health sciences 0302 clinical medicine Receptors KIR Pregnancy Genetics medicine Humans education Molecular Biology Genetic Association Studies Genetics (clinical) education.field_of_study Innate immune system biology Haplotype Hematopoietic Stem Cell Transplantation General Medicine medicine.disease Virology Immunity Innate Killer Cells Natural Receptors KIR2DL5 030104 developmental biology Haplotypes Cytomegalovirus Infections biology.protein Female Antibody 030215 immunology
Zdroj:	International Journal of Immunogenetics. 43:189-199
ISSN:	1744-3121
DOI:	10.1111/iji.12271
Popis:	Human cytomegalovirus (CMV) represents an important public health concern as it is associated with severe morbidity and mortality in transplant recipients, HIV-infected individuals and pregnant women given the risk of congenital infection. Congenital CMV is a leading cause of neurological sequelae, developmental delay and birth defects worldwide. Cytomegalovirus can be transmitted to the foetus following maternal infection or reactivation. NK cells expressing killer-cell immunoglobulin-like receptors (KIR) are part of the innate immune system and the first line of defence against viral incursions. Previous reports have shown that KIR genes are associated with CMV infections in the post-transplant setting. In this study, we set out to determine whether a protective effect of KIR genes over CMV infection is seen in Mexican pregnant women. Cytomegalovirus infection was assessed through nucleic acid testing in 200 pregnant women and 600 healthy blood donors comprising the Mexican mestizo reference population. Killer-cell immunoglobulin-like receptors and HLA-C genotypes were obtained from 200 pregnant women and 300 reference samples using a comprehensive PCR-SSP approach. We observed statistically lower carrier frequencies of cB03|tA01 gene-content haplotype, of cB03 haplotype motif, of the KIR2DL5 + 2DS3/2DS5 gene pair and of KIR2DL5 amongst CMV-positive pregnant women in comparison with those CMV negative. None of these were associated with CMV status in the reference population. Logistic regression analysis revealed that the most important factor determining CMV status during third-trimester pregnancies was the KIR2DL5 + 2DS3/2DS5 gene pair (OR 0.376 (95%CI 0.174, 0.811, P = 0.013). Our results indicate that CMV-protective KIR gene associations described in Caucasoid populations are also present in the genetically distinct Mexican mestizo population. Our results suggest that certain KIR gene combinations provide protection against CMV infections occurring during late-term pregnancies, a finding of utmost epidemiological importance given its implication with congenital CMV infections.
Databáze:	OpenAIRE
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