Targeting protein interaction networks in mitochondrial dynamics for cancer therapy
| Autor: | Hsuan Cheng Huang, Yi-Wen Chang, Hsueh Fen Juan, Chieh-Fan Yin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Cell type Cell Context (language use) Oxidative phosphorylation Mitochondrion Cell cycle Biology Mitochondrial Dynamics Cell biology Mitochondria Mitochondrial Proteins medicine.anatomical_structure Drug Delivery Systems mitochondrial fusion Neoplasms Drug Discovery medicine Humans Mitochondrial fission Protein Interaction Maps |
| Zdroj: | Drug discovery today. 27(4) |
| ISSN: | 1878-5832 |
| Popis: | Mitochondria are crucial organelles that provide energy via oxidative phosphorylation in eukaryotic cells and also have critical roles in growth, division, and the cell cycle, as well as the rapid adaptation required to meet the metabolic needs of the cell. Mitochondrial processes are highly dynamic; fusion and fission can vary with cell type, cellular context, and stress levels. Accumulating evidence demonstrates that an imbalance in mitochondrial dynamics leads to death in numerous types of human cancer cells. Therefore, modulating mitochondrial dynamics could be a therapeutic target. In this review, we provide an overview of the protein interaction networks involved in mitochondrial dynamics as effective and feasible drug targets and discuss the related potential therapeutic strategies for cancer. |
| Databáze: | OpenAIRE |
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