The George B. Koelle symposium on the cholinergic synapse
| Autor: | Bianchi Cp, Koelle Gb, O'Neill Jj |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Agrin
General Medicine Biology Synaptic Transmission Acetylcholine General Biochemistry Genetics and Molecular Biology Neuromuscular junction medicine.anatomical_structure Nicotinic agonist Cholinergic Fibers Postsynaptic potential Synapses Muscarinic acetylcholine receptor medicine Cholinergic Cholinergic synapse General Pharmacology Toxicology and Pharmaceutics Neuroscience Acetylcholine receptor |
| Zdroj: | Life Sciences. 50:PL91-PL99 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(92)90351-o |
| Popis: | The George B. Koelle Symposium on the Cholinergic Synapse described the early development of the importance of ACh as a transmitter at both cholinergic synapses of the CNS, ganglion and neuromuscular junction. While a great deal is known about the function of cholinergic transmission at the neuromuscular junction, the integrated role of cholinergic, nicotinic and muscarinic receptors in the overall process of CNS functions, i.e., behavior, motor control, abstract thinking, memory and speech remains as a challenge for future investigation. The architecture of the cholinergic synapse appears to be a dynamic process involving ARIA, Agrin and the various forms of ACh esterase. The regulation of gene expression and site directed localization of postsynaptic cholinergic receptor proteins during the life cycle involves the dynamic interactions of these agents with the postsynaptic membrane and postsynaptic gene express. The last two papers at the symposium dealt with the chemistry of the nicotinic receptor regulated channel involved in ACh binding and the consequent cationic channel conductional changes. |
| Databáze: | OpenAIRE |
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