Oxidative Stress and Antioxidant Status in High-Risk Prostate Cancer Subjects
| Autor: | Eswar Shankar, Lee Ponsky, Sanjay Gupta, Pingfu Fu, Janmejai K. Srivastava, Sanjeev Shukla, Haripaul Sharma, Gregory T. MacLennan, Rajnee Kanwal, Natarajan Bhaskaran, Akbar Nawab |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
inflammation 2 medicine.medical_specialty Antioxidant medicine.medical_treatment Clinical Biochemistry Glutathione reductase DNA damage 4 medicine.disease_cause Article Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine chemistry.chemical_classification lcsh:R5-920 biology Lipid peroxide Glutathione peroxidase oxidative stress 1 Glutathione prostate cancer 5 030104 developmental biology Endocrinology chemistry Catalase 030220 oncology & carcinogenesis biology.protein antioxidant enzymes 3 lcsh:Medicine (General) Oxidative stress |
| Zdroj: | Diagnostics Diagnostics, Vol 10, Iss 3, p 126 (2020) Volume 10 Issue 3 |
| ISSN: | 2075-4418 |
| Popis: | The oxidant/antioxidant balance has been implicated in the pathophysiology of prostate cancer. We investigated oxidative damage and antioxidant status in high-risk prostate cancer subjects. Reduced glutathione (GSH) levels were measured in erythrocytes, 8-hydroxydeoxyguanosine (8-OHdG) in leukocytes and plasma levels of catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), glutathione S-transferase (GST), superoxide dismutase (SOD), and lipid peroxide products were measured in high-risk and age-matched healthy subjects. Serum PSA levels were significantly higher (p < 0.0001) in high-risk subjects, whereas GST (p < 0.0001) and GSH (p < 0.002) were higher in healthy controls. Levels of 8-OHdG, an oxidized nucleoside of DNA, were significantly increased (p < 0.0001) in high-risk subjects. No marked difference in the levels of CAT (p = 0.237), GSH-Px (p = 0.74), GSH-R (p = 0.344), SOD (p = 0.109), and lipid peroxide products (p = 0129) were observed between two groups. Pearson&rsquo s correlation between GST and PSA (r = &minus 0.69 (p < 0.0001)), GST and 8-OHdG (r = &minus 0.62 (p < 0.0004)), GSH and 8-OHdG (r= &minus 0.39 (p = 0.038)), and CAT and GSH-Px (r= &minus 0.33 (p = 0.04)) were found to be negatively correlated, whereas 8-OHdG and PSA were positively associated (r= 0.57 (p < 0.002). These results indicate a significant role of oxidative damage in prostate carcinogenesis, particularly during the early stages of development. In conclusion, our data support the importance of antioxidant defense as a valuable diagnostic and/or prognostic marker in prostate cancer. |
| Databáze: | OpenAIRE |
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