The Eye as a Window to the Brain: Neuroretinal Thickness Is Associated With Microstructural White Matter Injury in HIV-Infected Children
| Autor: | Peter Reiss, Henriette J. Scherpbier, Dasja Pajkrt, Frank D. Verbraak, Charles B. L. M. Majoie, Ferdinand W. N. M. Wit, Matthan W.A. Caan, Sophie Cohen, Nazli Demirkaya, Charlotte Blokhuis, Michael D. Abràmoff |
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| Přispěvatelé: | Ophthalmology, Amsterdam Neuroscience - Neurovascular Disorders, Other departments, Global Health, Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, Radiology and Nuclear Medicine, Biomedical Engineering and Physics |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent HIV Infections Retina 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Retinal Diseases Fractional anisotropy medicine Humans Child Retinal thinning Brain Diseases medicine.diagnostic_test business.industry White Matter Injury Magnetic resonance imaging Retinal Organ Size Magnetic Resonance Imaging White Matter Cross-Sectional Studies medicine.anatomical_structure chemistry Case-Control Studies Female business Tomography Optical Coherence 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Investigative Ophthalmology and Visual Science, 57(8), 3864-3871 Investigative ophthalmology & visual science, 57(8), 3864-3871. Association for Research in Vision and Ophthalmology Inc. Blokhuis, C, Demirkaya, N, Cohen, S, Wit, F W N M, Scherpbier, H J, Reiss, P, Abramoff, M D, Caan, M W A, Majoie, C B L M, Verbraak, F D & Pajkrt, D 2016, ' The Eye as a Window to the Brain: Neuroretinal Thickness Is Associated With Microstructural White Matter Injury in HIV-Infected Children ', Investigative Ophthalmology and Visual Science, vol. 57, no. 8, pp. 3864-3871 . https://doi.org/10.1167/iovs.16-19716 |
| ISSN: | 0146-0404 3864-3871 |
| DOI: | 10.1167/iovs.16-19716 |
| Popis: | Purpose: Despite combination antiretroviral therapy (cART), perinatal HIV-infection can cause decreased gray and white matter volume, microstructural white matter injury, and retinal structural abnormalities. As neuroretinal tissue is directly connected to the brain, these deficits may have a shared pathogenesis. We aimed to assess associations between neuroretinal thickness and cerebral injury in cART-treated perinatally HIV-infected children and healthy controls.Methods: This cross-sectional observational study included 29 cART-treated perinatally HIV-infected children and 35 matched healthy controls. All participants underwent 3.0 Tesla magnetic resonance imaging (MRI), determining gray and white matter volumes from T1-weighted sequences, and white matter diffusivity using diffusion tensor imaging (DTI). Regional individual and total neuroretinal layer thickness was quantified using spectral-domain optical coherence tomography. We explored associations between retinal and cerebral parameters using multivariable linear regression analysis.Results: In HIV-infected children, lower foveal and pericentral neuroretinal thickness was associated with damaged white matter microstructure, in terms of lower fractional anisotropy and higher mean and radial diffusivity. In healthy controls only, neuroretinal thickness was associated with gray and white matter volume.Conclusions: Decreased neuroretinal thickness is associated with microstructural white matter injury, but not with lower cerebral volume in HIV-infected children. This suggests that HIV-induced retinal thinning and microstructural white matter injury may share a common pathogenesis, and longitudinal assessment of neuroretinal alterations in parallel with MRI and neuroinflammatory markers may further our insight into the pathogenesis of HIV-induced cerebral injury in children. |
| Databáze: | OpenAIRE |
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