| Autor: |
Felix Y. Feng, Eric J. Small, Alan Ashworth, Tomasz M. Beer, Jack Youngren, Charles Ryan, Christopher J. Lord, Karen Knudsen, Scott Tomlins, George Thomas, Colin Pritchard, Morgan Diolaiti, Rajdeep Das, Matti Annala, Kevin Beja, Jacob Schwartzman, Eric Lu, Won Kim, Rahul Aggarwal, Paul Lloyd, Adam Foye, Vishal Kothari, Alexander W. Wyatt, Joshi J. Alumkal, David Quigley |
| Rok vydání: |
2023 |
| DOI: |
10.1158/2159-8290.22532236 |
| Popis: |
Supplementary Table S1: Patient 1 reversion alleles. Supplementary Table 2: DNA read identifiers supporting reversion alleles. Supplementary Table S3: Gene targets of the SeqCap library used for cfDNA sequencing. Supplementary Figure S1: Frequent loss of heterozygosity in Patient 1's tumor DNA. Supplementary Figure S2: A single copy of chromosome 13 at the BRCA2 locus is present in Patient 1's tumor DNA. Supplementary Figure S3: Mutation signature three is present in patient 1's solid tumor. Supplementary Figure S4: A single copy of chromosome 13 at the BRCA2 locus is present in Patient 2's tumor DNA. Supplementary Figure S5: Patient 2's DNA coverage depth at residue 259. Supplementary Figure S6: Nucleotide and inferred protein sequences for patient 2's reversion alleles. Supplementary Figure S7: Reversion indels were significantly longer than the background distribution of indels. Supplementary Methods. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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