Epigenomic regulation by labile iron
| Autor: | Gaofeng Wang, Tyler C. Huff, Vladimir Camarena |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Epigenomics
0301 basic medicine biology Chemistry Iron Biological Transport Epigenome Biochemistry Article Trace Elements Ferrous Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine DNA demethylation Histone Physiology (medical) Histone methylation biology.protein Signal transduction 030217 neurology & neurosurgery Intracellular Signal Transduction |
| Zdroj: | Free Radic Biol Med |
| ISSN: | 0891-5849 |
| Popis: | Iron is an essential micronutrient metal for cellular functions but can generate highly reactive oxygen species resulting in oxidative damage. For these reasons its uptake and metabolism is highly regulated. A small but dynamic fraction of ferrous iron inside the cell, termed intracellular labile iron, is redox-reactive and ready to participate multiples reactions of intracellular enzymes. Due to its nature its determination and precise quantification has been a roadblock. However, recent progress in the development of intracellular labile iron probes are allowing the reevaluation of our current understanding and unmasking new functions. The role of intracellular labile iron in regulating the epigenome was recently discovered. This chapter examine how intracellular labile iron can modulate histone and DNA demethylation and how its pool can mediate a signaling pathway from cAMP serving as a sensor of the metabolic needs of the cells. |
| Databáze: | OpenAIRE |
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