Population receptive fields in non-human primates from whole-brain fmri and large-scale neurophysiology in visual cortex
| Autor: | Xing Chen, Pieter R. Roelfsema, Peter Christiaan Klink, Vim Vanduffel |
|---|---|
| Přispěvatelé: | Integrative Neurophysiology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Adult Psychiatry, Amsterdam Neuroscience - Systems & Network Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Life Sciences & Biomedicine - Other Topics
MONKEY CAUDATE NEURONS MACAQUE MONKEY Male genetic structures Computer science non-human primate Local field potential Signal 0302 clinical medicine Rhesus macaque Primate Magnetic Resonance Biology (General) SPATIAL SUMMATION Default mode network Visual Cortex Neurons Brain Mapping 0303 health sciences education.field_of_study neuroimaging biology General Neuroscience Brain Electroencephalography General Medicine Human brain Magnetic Resonance Imaging HEMODYNAMIC SIGNALS medicine.anatomical_structure population receptive field VENTRAL EXTRASTRIATE CORTEX Medicine Insight Life Sciences & Biomedicine vision QH301-705.5 Science Population nonhuman primate FUNCTIONAL-PROPERTIES VISUOTOPIC ORGANIZATION Summation General Biochemistry Genetics and Molecular Biology 03 medical and health sciences RETINOTOPIC ORGANIZATION Neuroimaging biology.animal medicine Animals education Biology TOPOGRAPHIC ORGANIZATION 030304 developmental biology Science & Technology General Immunology and Microbiology Neurophysiology Macaca mulatta Oxygen Visual cortex nervous system Regional Blood Flow Receptive field LATERAL GENICULATE-NUCLEUS neurophysiology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | eLife, 10:e67304, 1-35. eLife Sciences Publications ELIFE Christiaan Klink, P, Chen, X, Vanduffel, W & Roelfsema, P R 2021, ' Population receptive fields in non-human primates from whole-brain fmri and large-scale neurophysiology in visual cortex ', eLife, vol. 10, e67304, pp. 1-35 . https://doi.org/10.7554/eLife.67304 eLife, Vol 10 (2021) eLife eLife, 10:e67304. eLife Sciences Publications eLife, Vol. 10 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.67304 |
| Popis: | Population receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We addressed this question in awake nonhuman primates comparing whole-brain fMRI and large-scale neurophysiological recordings in areas V1 and V4 of the visual cortex. We examined the fits of several pRF models based on the fMRI blood-oxygen-level-dependent (BOLD) signal, multi-unit spiking activity (MUA), and local field potential (LFP) power in different frequency bands. We found that pRFs derived from BOLD-fMRI were most similar to MUA-pRFs in V1 and V4, while pRFs based on LFP gamma power also gave a good approximation. fMRI-based pRFs thus reliably reflect neuronal receptive field properties in the primate brain. In addition to our results in V1 and V4, the whole-brain fMRI measurements revealed retinotopic tuning in many other cortical and subcortical areas with a consistent increase in pRF size with increasing eccentricity, as well as a retinotopically specific deactivation of default mode network nodes similar to previous observations in humans. ispartof: ELIFE vol:10 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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