Synchronous diagnosis of anaplastic large cell lymphoma and multiple myeloma in a patient: A case report

Autor: Min Chen, Tiantian Li, Yichen Liu, Xiaodong Xi, Wanru Chen, Jian-Nong Wu, Shuo Zhang, Jie Peng, Yan Zhu, Qian Jiang, Xiaofeng Shi, Xianqiu Yu
Rok vydání: 2020
Předmět:
Skin Neoplasms
co-existence
Dexamethasone
Neoplasms
Multiple Primary
0302 clinical medicine
Autologous stem-cell transplantation
hemic and lymphatic diseases
Positron Emission Tomography Computed Tomography
Antineoplastic Combined Chemotherapy Protocols
030212 general & internal medicine
Anaplastic large-cell lymphoma
Lenalidomide
Multiple myeloma
Etoposide
Remission Induction
Hematopoietic Stem Cell Transplantation
Bone Marrow Examination
General Medicine
Middle Aged
Immunohistochemistry
ALK-negative
multiple myeloma
Vincristine
anaplastic large cell lymphoma
030220 oncology & carcinogenesis
Lymphoma
Large-Cell
Anaplastic
Female
Radiology
medicine.drug
Research Article
medicine.medical_specialty
Transplantation
Autologous
Maintenance Chemotherapy
03 medical and health sciences
Bleomycin
medicine
Humans
Clinical Case Report
Cyclophosphamide
business.industry
Large cell
Abdominal Wall
medicine.disease
Lymphoma
Transplantation
Regimen
Doxorubicin
Prednisone
business
Zdroj: Medicine
ISSN: 1536-5964
Popis: Rationale: Synchronous development of both anaplastic large cell lymphoma (ALCL) and multiple myeloma (MM) in a patient is rare. To our knowledge, until now only one case has been reported. Treatment needs to cover both and is a challenge. Here we reported another case and discussed the diagnosis and treatment. Patient concerns: This is a 63-year old woman who presented with a mass in upper abdominal skin. Positron emission tomography/computed tomography (PET/CT) showed the high metabolism in left abdominal skin and left axillary lymph nodes. Histopathologic and immunohistochemical evaluation identified the cutaneous mass as an ALK-negative ALCL. Bone marrow smear showed increased plasma cells which expressed CD38, CD138, and cLambda concomitantly. The increased monoclonal immunoglobulin IgD λ was detected by immunofixation electrophoresis. Diagnoses: Diagnosis of both ALCL and MM was confirmed. Interventions: The patient successively received 6 cycles of B-CHOD regimen, one cycle of ID regimen, 2 cycles of DHAX regimen, one cycle of L-DA-EPOCH and autologous stem cell transplantation (ASCT). Then lenalidomide was performed as a maintenance therapy. Outcomes: Both ALCL and MM achieved complete remission. Lessons: We reported a very rare case with synchronous development of ALCL and MM, in whom a good therapeutic response to chemotherapies followed by ASCT has been observed.
Databáze: OpenAIRE
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