Psychotherapy and phosphodiesterase-5 inhibitor in early rehabilitation after radical prostatectomy: a prospective randomised controlled trial

Autor:	A.M.E.P. Naccarato, Ubirajara Ferreira, Leonardo Oliveira Reis, Fernandes Denardi
Rok vydání:	2016
Předmět:	Adult Male medicine.medical_specialty medicine.drug_mechanism_of_action Urology medicine.medical_treatment Carbonates 030232 urology & nephrology Piperazines law.invention Group psychotherapy 03 medical and health sciences 0302 clinical medicine Endocrinology Erectile Dysfunction Randomized controlled trial Quality of life law Humans Medicine Prospective Studies Aged Prostatectomy business.industry Penile Erection Prostatic Neoplasms Lodenafil General Medicine Middle Aged Phosphodiesterase 5 Inhibitors medicine.disease Combined Modality Therapy Psychotherapy Pyrimidines Treatment Outcome Erectile dysfunction 030220 oncology & carcinogenesis Sex life Quality of Life Physical therapy business Phosphodiesterase 5 inhibitor
Zdroj:	Andrologia. 48:1183-1187
ISSN:	0303-4569
Popis:	Summary The aim of this study was to evaluate the impact of group psychotherapy and the use of a phosphodiesterase-5 inhibitor (PDE-5i) in the early rehabilitation stage of patients with prostate cancer undergoing radical prostatectomy (RP). Fifty-six patients undergoing RP for prostate cancer were randomised into four groups, and 53 completed the protocol: Group 1 – control (n = 11), Group 2 – group psychotherapy (n = 16), Group 3 – lodenafil 80 mg/one tablet per week (n = 12) and Group 4 – group psychotherapy + lodenafil 80 mg/one tablet per week (n = 14). The groups were individually evaluated for erectile function (IIEF-5) and quality of life – QoL (SF-36) weekly, with two meetings held a week apart before the RP and 12 weekly meetings after surgery. The ages ranged from 39 to 76 years, average 61.84. There were no significant medication side effects. Only Group 4 showed improvement in intimacy with a partner and satisfaction with their sex life (P = 0.045 and P = 0.013 respectively), and with no significant worsening of the IIEF-5 (P = 0.250) reported. All groups showed worsening in the final result of the role limitations caused by physical problems (P = 0.009) and role limitations caused by emotional problems (P = 0.002) of the SF-36, but Group 4 had a significantly higher score for the role limitations caused by physical problems (P = 0.009) than the other groups. In conclusion, precocious integral treatment involving group psychotherapy and PDE-5i before and after RP led to less deterioration of erectile function and other domains related to physical aspects (SF-36), with improvement in intimacy with their partner and satisfaction in their sex life, being superior to single treatments.
Databáze:	OpenAIRE
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