Coronary 18 F-Fluoride Uptake and Progression of Coronary Artery Calcification
| Autor: | Michelle C. Williams, Rebecca Gillen, Mohammed N. Meah, Marwa Daghem, Alastair J Moss, David E. Newby, Philip D Adamson, Mhairi K. Doris, Marc R. Dweck, Piotr J. Slomka, Damini Dey, Nick Weir, Maaz Syed, Anoop S V Shah, Rong Bing, Jack P.M. Andrews, Edwin J R van Beek, Laura Forsyth |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry chemistry.chemical_element Calcium medicine.disease Coronary artery disease Coronary circulation medicine.anatomical_structure chemistry Positron emission tomography Internal medicine Angiography Cardiology Medicine Radiology Nuclear Medicine and imaging Cardiology and Cardiovascular Medicine business Coronary atherosclerosis Calcification Computed tomography angiography |
| Zdroj: | Doris, M, Meah, M, Moss, A, Andrews, J, Bing, R, Gillen, R, Weir, N, Syed, M, Daghem, M, Shah, A, Williams, M C, van Beek, E J R, Forsyth, L, Dey, D, Slomka, P J, Dweck, M R, Newby, D E & Adamson, P D 2020, ' Coronary 18F-Fluoride Uptake and Progression of Coronary Artery Calcification ', Circulation: Cardiovascular Imaging . https://doi.org/10.1161/CIRCIMAGING.120.011438 |
| ISSN: | 1942-0080 1941-9651 |
| Popis: | Background Positron emission tomography (PET) using 18 F-sodium fluoride ( 18 F-fluoride) to detect microcalcification may provide insight into disease activity in coronary atherosclerosis. This study aimed to investigate the relationship between 18 F-fluoride uptake and progression of coronary calcification in patients with clinically stable coronary artery disease. Methods Patients with established multivessel coronary atherosclerosis underwent 18 F-fluoride PET-computed tomography angiography and computed tomography calcium scoring, with repeat computed tomography angiography and calcium scoring at one year. Coronary PET uptake was analyzed qualitatively and semiquantitatively in diseased vessels by measuring maximum tissue-to-background ratio. Coronary calcification was quantified by measuring calcium score, mass, and volume. Results In a total of 183 participants (median age 66 years, 80% male), 116 (63%) patients had increased 18 F-fluoride uptake in at least one vessel. Individuals with increased 18 F-fluoride uptake demonstrated more rapid progression of calcification compared with those without uptake (change in calcium score, 97 [39–166] versus 35 [7–93] AU; P 18 F-fluoride uptake (from 95 [30–209] to 148 [61–289] AU; P 18 F-fluoride uptake (from 46 [16–113] to 49 [20–115] AU; P =0.329). Baseline coronary 18 F-fluoride maximum tissue-to-background ratio correlated with 1-year change in calcium score, calcium volume, and calcium mass (Spearman ρ=0.37, 0.38, and 0.46, respectively; P 18 F-fluoride activity was an independent predictor of calcium score at 12 months ( P P =0.50). Conclusions Coronary 18 F-fluoride uptake identifies both patients and individual coronary segments with more rapid progression of coronary calcification, providing important insights into disease activity within the coronary circulation. At the individual patient level, total calcium score remains an important marker of disease burden and progression. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02110303. |
| Databáze: | OpenAIRE |
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