Host transcriptome and microbiome interaction modulates physiology of full-sibs broilers with divergent feed conversion ratio
| Autor: | Jignasha G. Patel, Tejas M. Shah, Chaitanya G. Joshi, Damer P. Blake, Tejas P. Gohil |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbial diversity chemical and pharmacologic phenomena Biology Weight Gain Applied Microbiology and Biotechnology Microbiology Feed conversion ratio lcsh:Microbial ecology Article Transcriptome 03 medical and health sciences 0302 clinical medicine Animals Microbiome Gene Genetics Host Microbial Interactions Gene Expression Profiling Siblings Broiler Animal Feed Gastrointestinal Microbiome Intestines 030104 developmental biology Intestinal homeostasis Liver Metagenomics 030220 oncology & carcinogenesis lcsh:QR100-130 Chickens Biotechnology |
| Zdroj: | NPJ Biofilms and Microbiomes npj Biofilms and Microbiomes, Vol 5, Iss 1, Pp 1-13 (2019) |
| ISSN: | 2055-5008 |
| DOI: | 10.1038/s41522-019-0096-3 |
| Popis: | Efficient livestock production relies on effective conversion of feed into body weight gain (BWG). High levels of feed conversion are especially important in production of broiler chickens, birds reared for meat, where economic margins are tight. Traits associated with improved broiler growth and feed efficiency have been subjected to intense genetic selection, but measures such as feed conversion ratio (FCR) remain variable, even between full siblings (sibs). Non-genetic factors such as the composition and function of microbial populations within different enteric compartments have been recognized to influence FCR, although the extent of interplay between hosts and their microbiomes is unclear. To examine host–microbiome interactions we investigated variation in the composition and functions of host intestinal-hepatic transcriptomes and the intestinal microbiota of full-sib broilers with divergent FCR. Progeny from 300 broiler families were assessed for divergent FCR set against shared genetic backgrounds and exposure to the same environmental factors. The seven most divergent full-sib pairs were chosen for analysis, exhibiting marked variation in transcription of genes as well as gut microbial diversity. Examination of enteric microbiota in low FCR sibs revealed variation in microbial community structure and function with no difference in feed intake compared to high FCR sibs. Gene transcription in low and high FCR sibs was significantly associated with the abundance of specific microbial taxa. Highly intertwined interactions between host transcriptomes and enteric microbiota are likely to modulate complex traits like FCR and may be amenable to selective modification with relevance to improving intestinal homeostasis and health. |
| Databáze: | OpenAIRE |
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