Nogo-A downregulation impairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze
| Autor: | Kai Schönig, Karel Vales, Tomas Petrasek, Stepan Bahnik, Dusan Bartsch, Iva Prokopova, Stefan P Berger, Björn Tews, Martin E. Schwab, Ales Stuchlik |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Nogo Proteins Cognitive Neuroscience Rat model Down-Regulation Spatial Behavior Morris water navigation task Experimental and Cognitive Psychology Spatial memory Rats Sprague-Dawley Behavioral Neuroscience Downregulation and upregulation mental disorders Neuroplasticity Avoidance Learning medicine Animals Maze Learning Cognitive deficit medicine.disease Rats Schizophrenia Gene Knockdown Techniques Rats Transgenic medicine.symptom Psychology Neuroscience Myelin Proteins psychological phenomena and processes |
| Zdroj: | Neurobiology of Learning and Memory |
| ISSN: | 1074-7427 |
| DOI: | 10.1016/j.nlm.2013.10.015 |
| Popis: | Nogo A protein is an important inhibitor of axonal growth which also regulates neuronal plasticity in the CNS. Mutations in the gene encoding Nogo A or abnormalities in Nogo A expression are linked to neuropsychiatric disorders such as schizophrenia. The present study assesses the impact of constitutively reduced expression of Nogo A on place navigation in a novel transgenic rat model. Two spatial paradigms were used: (1) A battery of tests in the Carousel maze requiring continuous processing of spatial information with increasing demands for the segregation of reference frames and behavioral flexibility and (2) a delayed matching to place version of the Morris water maze (MWM) which requires place navigation and is sensitive to deficits in one trial encoded place representation. The Carousel maze testing revealed a subtle but significant impairment in management of reference frames. Matching to place learning in the Morris water maze was unaffected suggesting an intact representation of an unmarked goal. Our results show that Nogo A deficiency leads to cognitive deficit in processing of the reference frames. Such a deficit may be the result of neuro developmental alterations resulting from Nogo A deficiency. © 2013 Elsevier Inc. |
| Databáze: | OpenAIRE |
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