Ca2+-Mg2+-ATPase activity and ionized calcium in Type 2 diabetic patients with neuropathy
| Autor: | K Xenos, Karmaniolas Kd, E Leontiades, I.N Migdalis, K Chairopoulos, N Varvarigos |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Diabetic neuropathy Endocrinology Diabetes and Metabolism ATPase chemistry.chemical_element Calcium Calcium in biology Endocrinology Diabetic Neuropathies Reference Values Internal medicine Diabetes mellitus Blood plasma Internal Medicine medicine Humans Magnesium Glycated Hemoglobin Calcium metabolism biology business.industry General Medicine Middle Aged medicine.disease Peripheral neuropathy Diabetes Mellitus Type 2 chemistry Parathyroid Hormone biology.protein Female Ca(2+) Mg(2+)-ATPase business |
| Zdroj: | Diabetes Research and Clinical Practice. 49:113-118 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/s0168-8227(00)00150-9 |
| Popis: | Ca(2+)-Mg(2+)-ATPase is an important regulator of intracellular calcium concentration and therefore, of erythrocyte deformability. We have investigated the possible relationship between Ca(2+)-Mg(2+)-ATPase activity (ATPase) and ionized calcium (Ca(2+)), in diabetic patients with peripheral neuropathy. A total of 104 Type 2 diabetic patients (57 neuropathic and 47 non-neuropathic) and 25 non-diabetic subjects were studied. After an overnight fast, blood was taken for Ca(2+)-Mg(2+)-ATPase activity, Ca(2+), Mg(2+), PTH and HbA(1c). The neuropathy study group had significantly lower levels of ATPase, 6.6 (95% CI, 5.6-7.7) nmol/mg/min compared to controls 7. 1 (6.2-8.3) nmol/mg/min, P0.001 and to diabetic patients without neuropathy 7.0 (6.0-8.1) nmol/mg/min, P0.001. The study group had also lower levels of Ca(2+) (0.89+/-0.18 mmol/l vs. control 1.08+/-0. 24 mmol/l, P0.01 and non-neuropathic 0.98+/-0.27 mmol/l, P0.05) and Mg(2+) (0.73+/-0.13 mmol/l vs. control 0.81+/-0.14 mmol/l, P0. 05), despite similar PTH levels. In diabetic subjects, no correlation was found between ATPase or Ca(2+) with glucose, HbA(1c), age or duration of diabetes. We conclude that in patients with diabetic neuropathy there are abnormalities of Ca(2+)-Mg(2+)-ATPase activity and Ca(2+). This provides further support for the role of microangiopathy in the pathogenesis of neuropathy. |
| Databáze: | OpenAIRE |
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