Solubilized eggshell membrane supplies a type III collagen-rich elastic dermal papilla
| Autor: | Masashi Kurimoto, Yoriko Atomi, Taku Takami, Miho Shimizu, Kotaro Yoshimura, Tomoaki Murakami, Kai Yamazawa, Yukio Hasebe, Yoshihiko Murakami, Shoei Sano, Tomoaki Atomi, Eri Ohto-Fujita, Takashi Sakurai |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Histology Collagen Type I Pathology and Forensic Medicine Extracellular matrix Andrology Egg Shell Mice 03 medical and health sciences 0302 clinical medicine Dermis medicine Animals Humans Cells Cultured Mice Hairless integumentary system Chemistry Papillary dermis Cell Biology Fibroblasts Elasticity Extracellular Matrix Skin Aging Hairless Staining Collagen Type III 030104 developmental biology medicine.anatomical_structure Dermal papillae Solubility Medicine Traditional Eggshell membrane 030217 neurology & neurosurgery Type I collagen |
| Zdroj: | Cell and Tissue Research. 376:123-135 |
| ISSN: | 1432-0878 0302-766X |
| DOI: | 10.1007/s00441-018-2954-3 |
| Popis: | Signs of aging in facial skin correlate with lifespan and chronic disease; however, the health of aging skin has not been extensively studied. In healthy young skin, the dermis forms a type III collagen-rich dermal papilla, where capillary vessels supply oxygen and nutrients to basal epidermal cells. Chicken eggshell membranes (ESMs) have been used as traditional medicines to promote skin wound healing in Asian countries for many years. Previously, we designed an experimental system in which human dermal fibroblasts (HDFs) were cultured on a dish with a solubilized ESM (S-ESM) bound to an artificial phosphorylcholine polymer; we found that genes that promoted the health of the papillary dermis, such as those encoding type III collagen, were induced in the S-ESM environment. The present study found that a gel with a ratio of 20% type III/80% type I collagen, similar to that of the baby skin, resulted in a higher elasticity than 100% type I collagen (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink