Specific Features of TLR4 Expression in Structural Elements of Placenta in Patients with Preeclampsia
| Autor: | N. S. Loginova, V. L. Tyutyunnik, N. E. Kan, M. N. Nagovitsina, V. M. Lyapin, G V Kulikova, N V Nizyaeva, N. V. Tyutyunnik, A. I. Schegolev |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endothelium Placenta General Biochemistry Genetics and Molecular Biology Preeclampsia 03 medical and health sciences 0302 clinical medicine Syncytiotrophoblast Pre-Eclampsia Pregnancy Internal medicine medicine Humans Endothelial dysfunction reproductive and urinary physiology 030219 obstetrics & reproductive medicine Obstetrics business.industry Endothelial Cells Trophoblast General Medicine medicine.disease female genital diseases and pregnancy complications Trophoblasts Toll-Like Receptor 4 030104 developmental biology medicine.anatomical_structure Endocrinology embryonic structures TLR4 Chorionic villi Female Chorionic Villi business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 160:718-721 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-016-3259-8 |
| Popis: | We studied the expression of TLR4 (Toll-like receptor 4) in the syncytiotrophoblast and vascular endothelial cells of terminal and stem placental villi in severe preeclampsia and normal pregnancy. In women of both groups, the expression of TLR4 was higher in the syncytiotrophoblast that in placental endothelial cells. In patients with severe preeclampsia, TLR4 expression in endothelial cells of terminal villi was 1.3-fold lower than in normal pregnancy. Lower TLR4 expression in the terminal villi endothelium in preeclampsia can underlie impaired recognition of damaging molecules with subsequent development of endothelial dysfunction and changes in immunological tolerance. |
| Databáze: | OpenAIRE |
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