Renin-Angiotensin-Aldosterone System Blockade in Diabetic Nephropathy. Present Evidences
| Autor: | Adriana Puente-García, Luz Lozano-Maneiro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
ACE inhibitors direct renin inhibitors lcsh:Medicine Disease Review Pharmacology Diabetic nephropathy Mineralocorticoid receptor Internal medicine Diabetes mellitus renin-angiotensin-aldosterone system blockade Renin–angiotensin system medicine mineralocorticoid receptor antagonists business.industry diabetic nephropathy lcsh:R General Medicine medicine.disease diabetic kidney disease Blockade Clinical trial angiotensin receptor blockers combined RAAS blockade Cardiology dual RAAS blockade business aldosterone antagonist Kidney disease |
| Zdroj: | Journal of Clinical Medicine, Vol 4, Iss 11, Pp 1908-1937 (2015) Journal of Clinical Medicine Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| ISSN: | 2077-0383 |
| Popis: | Diabetic Kidney Disease (DKD) is the leading cause of chronic kidney disease in developed countries and its prevalence has increased dramatically in the past few decades. These patients are at an increased risk for premature death, cardiovascular disease, and other severe illnesses that result in frequent hospitalizations and increased health-care utilization. Although much progress has been made in slowing the progression of diabetic nephropathy, renal dysfunction and the development of end-stage renal disease remain major concerns in diabetes. Dysregulation of the renin-angiotensin-aldosterone system (RAAS) results in progressive renal damage. RAAS blockade is the cornerstone of treatment of DKD, with proven efficacy in many arenas. The theoretically-attractive option of combining these medications that target different points in the pathway, potentially offering a more complete RAAS blockade, has also been tested in clinical trials, but long-term outcomes were disappointing. This review examines the “state of play” for RAAS blockade in DKD, dual blockade of various combinations, and a perspective on its benefits and potential risks. |
| Databáze: | OpenAIRE |
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