Expression Profile of Survivin and p16 in Laryngeal Squamous Cell Carcinoma: Contribution of Tunisian Patients
| Autor: | Mariem Ben Elhadj, Aida Goucha, Wided Ben Ayoub, Nehla Mokni Baizig, Michèle-Veronique El May, Asma Fourati, Olfa El Amine |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male medicine.medical_specialty Tunisia medicine.medical_treatment Survivin Gene Expression Kaplan-Meier Estimate Disease-Free Survival Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Lymph node Laryngeal Neoplasms Survival analysis 030304 developmental biology Aged Retrospective Studies Aged 80 and over 0303 health sciences Chemotherapy business.industry Genes p16 Cancer Middle Aged Laryngeal squamous cell carcinoma medicine.disease Prognosis Immunohistochemistry Survival Rate medicine.anatomical_structure Otorhinolaryngology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Lymphatic Metastasis Multivariate Analysis Carcinoma Squamous Cell Female business |
| Zdroj: | Ear, nose,throat journal. 100(1) |
| ISSN: | 1942-7522 |
| Popis: | The objective of this study was to evaluate the expression of survivin and p16 in laryngeal squamous cell carcinoma (LSCC) in order to analyze their pathogenesis and prognostic significance in Tunisian patients. A total of 70 patients with LSCC collected at the Salah Azaiez Cancer Institute of Tunis were retrospectively evaluated. Expression of survivin and p16 was examined using immunohistochemistry, and the correlations with clinicopathological parameters, overall survival (OS), and disease-free survival (DFS) were statistically evaluated. The positive expression of survivin and p16 were found in 58.6% and 51.43% of LSCC cases, respectively. The p16 expression was not associated with either clinical parameters or patient survival, whereas there was a strong correlation of survivin expression and lymph node metastases ( P = .002), alcohol consumption ( P = .024), and therapeutic protocol (with or without chemotherapy; P = .001). Kaplan-Meier survival curves showed that patients with LSCC having positive survivin expression have shorter OS ( P = .026) and shorter DFS ( P = .01) than those with negative expression. Positive survivin expression was also correlated with high recurrence rate ( P = .014). Therefore, survivin is a poor prognostic marker for LSCC but the therapeutic protocol remains, in multivariate study, the most decisive for the OS and DFS of our patients with P < .01. Our data indicated that, in Tunisian laryngeal squamous cell carcinoma, survivin expression is associated with unfavorable outcomes and represents a predictor marker of recurrence and chemoresistance. However, p16 expression has no prognosis value. |
| Databáze: | OpenAIRE |
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