Evaluation of the Effect of Low-Dose Aspirin on Biochemical and Biophysical Biomarkers for Placental Disease in Low-Risk Pregnancy: Secondary Analysis of a Multicenter RCT
| Autor: | Eoghan E. Mooney, Cecilia Mulcahy, Orla C Maguire, Paul Downey, Marie Culliton, Elizabeth Tully, Philip Clarke, Peter McParland, Fergal D. Malone, Fionnuala Mone, Fionnuala M. McAuliffe, David Fitzgerald |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Placenta Diseases Birth weight Urinary system Placenta Gastroenterology Ultrasonography Prenatal Preeclampsia Fetal Development 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Internal medicine medicine Albuminuria Humans Pregnancy-Associated Plasma Protein-A Placenta Growth Factor Aspirin 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology medicine.disease Placental disease Blood pressure Creatinine Pediatrics Perinatology and Child Health Female medicine.symptom business Biomarkers medicine.drug |
| Zdroj: | American journal of perinatology. 36(13) |
| ISSN: | 1098-8785 |
| Popis: | Objective To assess the effect of aspirin use in low-risk pregnancy on: (1) pregnancy-associated plasma protein-A (PAPP-A) and placental-like growth factor (PLGF); (2) urinary albumin-to-creatinine ratio (ACR) and blood pressure; (3) fetal growth parameters; and (4) placental histopathology. Study Design This secondary analysis from the T rial of low-dose aspirin with an E arly S creening T est for preeclampsia and growth restriction randomized controlled trial was based on low-risk nulliparous women randomized at 11 weeks to (1) aspirin 75 mg; (2) no aspirin; and (3) aspirin based on the preeclampsia Fetal Medicine Foundation screening test. At baseline, women underwent assessment of blood pressure, PAPP-A, PLGF, and ACR, repeated 9 to 10 weeks postaspirin, in addition to fetal growth assessment. Gross and histopathological placental analyses were performed in line with Amsterdam criteria. Results A total of 445 subjects were included (aspirin n = 163 [36.6%]; no aspirin n = 282 [63.4%]). Although the fetal-to-placental weight ratio was significantly greater in the aspirin group (7.5 [±1.3] vs. 7.3 [±1.4], p = 0.045), as was change in ultrasound assessed estimated fetal weight from second to third trimesters (1,624.5 g [±235.1] vs. 1,606.2 [±189.4], p = 0.042), this was invalidated by the lack of a difference in birth weight. Aspirin did not significantly impact on change in serum or urine preeclampsia biomarkers, maternal blood pressure, or placental histopathology. Conclusion Aspirin use in low-risk pregnancy does not appear to impact on preeclampsia biomarkers, fetal growth, or placental pathology. |
| Databáze: | OpenAIRE |
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