Cannabinoid receptors in microglia of the central nervous system: immune functional relevance
| Autor: | F. Marciano‐Cabral, G. A. Cabral |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Central Nervous System
Chemokine Cannabinoid receptor medicine.medical_treatment Immunology Biology Receptor Cannabinoid CB2 Immune system Receptor Cannabinoid CB1 Cannabinoid receptor type 2 medicine Immunology and Allergy Animals Humans Gliosis Receptor Receptors Cannabinoid Microglia Cannabinoids Cell Biology medicine.anatomical_structure Immune System biology.protein GPR18 Encephalitis lipids (amino acids peptides and proteins) Cannabinoid Neuroscience |
| Zdroj: | Journal of leukocyte biology. 78(6) |
| ISSN: | 0741-5400 |
| Popis: | Microglia, resident macrophages of the brain, function as immune effector and accessory cells. Paradoxically, they not only play a role in host defense and tissue repair but also have been implicated in a variety of neuropathological processes. Microglia, in addition to exhibiting phenotypic markers for macrophages, express CB1 and CB2 cannabinoid receptors. Recent studies suggest the existence of a third, yet-to-be cloned, non-CB1, non-CB2 cannabinoid receptor. These receptors appear to be functionally relevant within defined windows of microglial activation state and have been implicated as linked to cannabinoid modulation of chemokine and cytokine expression. The recognition that microglia express cannabinoid receptors and that their activation results in modulation of select cellular activities suggests that they may be amenable to therapeutic manipulation for ablating untoward inflammatory responses in the central nervous system. |
| Databáze: | OpenAIRE |
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